What risk of death would people take to be cured of HIV and why? A survey of people living with HIV

What risk of death would people take to be cured of HIV and why? A survey of people living with HIV

People living with HIV (PLWHIV) can reasonably expect near-normal longevity, yet many express a willingness to assume significant risks to be cured. We surveyed 200 PLWHIV who were stable on antiretroviral therapy (ART) to quantify associations between the benefits they anticipate from a cure and th...

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Main Authors: Benjamin R. Murray, Allison Kratka, Karen A. Scherr, Nir Eyal, Jennifer Blumenthal-Barby, Kenneth A. Freedberg, Daniel R. Kuritzkes, James K. Hammitt, Regina Edifor, Madelaine N. Katz, Kathryn I. Pollak, Brian J. Zikmund-Fisher, Scott D. Halpern, Mary C. Barks, Peter A. Ubel
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Journal of Virus Eradication
Subjects:
HIV
medication
risk taking
treatment
Online Access:http://www.sciencedirect.com/science/article/pii/S2055664020300522
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spelling doaj-5d21c49670694a2c9bd4251551087dc52021-05-05T04:04:13ZengElsevierJournal of Virus Eradication2055-66402019-04-0152109115What risk of death would people take to be cured of HIV and why? A survey of people living with HIVBenjamin R. Murray0Allison Kratka1Karen A. Scherr2Nir Eyal3Jennifer Blumenthal-Barby4Kenneth A. Freedberg5Daniel R. Kuritzkes6James K. Hammitt7Regina Edifor8Madelaine N. Katz9Kathryn I. Pollak10Brian J. Zikmund-Fisher11Scott D. Halpern12Mary C. Barks13Peter A. Ubel14Duke University School of Medicine, Durham, NC, USADuke University School of Medicine, Durham, NC, USADuke University School of Medicine, Durham, NC, USA; Duke University Fuqua School of Business, Durham, NC, USAHarvard TH Chan School of Public Health, Boston, MA, USABaylor College of Medicine, Center for Medical Ethics and Health Policy, Houston, TX, USAHarvard TH Chan School of Public Health, Boston, MA, USA; Medical Practice Evaluation Center, Divisions of General Internal Medicine and Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Harvard Medical School, Boston, MA, USAHarvard Medical School, Boston, MA, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USAHarvard TH Chan School of Public Health, Boston, MA, USA; Toulouse School of Economics, University of Toulouse Capitole, Toulouse, FranceUniversity of Massachusetts Medical School, Worcester, MA, USADuke University Fuqua School of Business, Durham, NC, USA; Duke-Margolis Center for Health Policy, Duke University, Durham, NC, USADuke University School of Medicine, Durham, NC, USA; Population Health Sciences, Cancer Control and Population Sciences, Duke Cancer Institute, Durham, NC, USADepartment of Health Behavior and Health Education, University of Michigan School of Public Health, Ann Arbor, MI, USA; Center for Bioethics and Social Sciences in Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USADepartments of Medicine and Medical Ethics in Health Policy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USADuke University Fuqua School of Business, Durham, NC, USA; Duke-Margolis Center for Health Policy, Duke University, Durham, NC, USADuke University School of Medicine, Durham, NC, USA; Duke University Fuqua School of Business, Durham, NC, USA; Duke-Margolis Center for Health Policy, Duke University, Durham, NC, USA; Corresponding author: Peter A. Ubel100 Fuqua Drive, Durham, NC27708People living with HIV (PLWHIV) can reasonably expect near-normal longevity, yet many express a willingness to assume significant risks to be cured. We surveyed 200 PLWHIV who were stable on antiretroviral therapy (ART) to quantify associations between the benefits they anticipate from a cure and their risk tolerance for curative treatments. Sixty-five per cent expected their health to improve if cured of HIV, 41% predicted the virus would stop responding to medications over the next 20 years and 54% predicted experiencing serious medication side effects in the next 20 years. Respondents’ willingness to risk death for a cure varied widely (median 10%, 75th percentile 50%). In multivariate analyses, willingness to risk death was associated with expected long-term side effects of ART, greater financial resources and being employed (all P < 0.05) but was not associated with perceptions of how their health would improve if cured.http://www.sciencedirect.com/science/article/pii/S2055664020300522HIVmedicationrisk takingtreatment
collection DOAJ
language English
format Article
sources DOAJ
author Benjamin R. Murray
Allison Kratka
Karen A. Scherr
Nir Eyal
Jennifer Blumenthal-Barby
Kenneth A. Freedberg
Daniel R. Kuritzkes
James K. Hammitt
Regina Edifor
Madelaine N. Katz
Kathryn I. Pollak
Brian J. Zikmund-Fisher
Scott D. Halpern
Mary C. Barks
Peter A. Ubel
spellingShingle Benjamin R. Murray
Allison Kratka
Karen A. Scherr
Nir Eyal
Jennifer Blumenthal-Barby
Kenneth A. Freedberg
Daniel R. Kuritzkes
James K. Hammitt
Regina Edifor
Madelaine N. Katz
Kathryn I. Pollak
Brian J. Zikmund-Fisher
Scott D. Halpern
Mary C. Barks
Peter A. Ubel
What risk of death would people take to be cured of HIV and why? A survey of people living with HIV
Journal of Virus Eradication
HIV
medication
risk taking
treatment
author_facet Benjamin R. Murray
Allison Kratka
Karen A. Scherr
Nir Eyal
Jennifer Blumenthal-Barby
Kenneth A. Freedberg
Daniel R. Kuritzkes
James K. Hammitt
Regina Edifor
Madelaine N. Katz
Kathryn I. Pollak
Brian J. Zikmund-Fisher
Scott D. Halpern
Mary C. Barks
Peter A. Ubel
author_sort Benjamin R. Murray
title What risk of death would people take to be cured of HIV and why? A survey of people living with HIV
title_short What risk of death would people take to be cured of HIV and why? A survey of people living with HIV
title_full What risk of death would people take to be cured of HIV and why? A survey of people living with HIV
title_fullStr What risk of death would people take to be cured of HIV and why? A survey of people living with HIV
title_full_unstemmed What risk of death would people take to be cured of HIV and why? A survey of people living with HIV
title_sort what risk of death would people take to be cured of hiv and why? a survey of people living with hiv
publisher Elsevier
series Journal of Virus Eradication
issn 2055-6640
publishDate 2019-04-01
description People living with HIV (PLWHIV) can reasonably expect near-normal longevity, yet many express a willingness to assume significant risks to be cured. We surveyed 200 PLWHIV who were stable on antiretroviral therapy (ART) to quantify associations between the benefits they anticipate from a cure and their risk tolerance for curative treatments. Sixty-five per cent expected their health to improve if cured of HIV, 41% predicted the virus would stop responding to medications over the next 20 years and 54% predicted experiencing serious medication side effects in the next 20 years. Respondents’ willingness to risk death for a cure varied widely (median 10%, 75th percentile 50%). In multivariate analyses, willingness to risk death was associated with expected long-term side effects of ART, greater financial resources and being employed (all P < 0.05) but was not associated with perceptions of how their health would improve if cured.
topic HIV
medication
risk taking
treatment
url http://www.sciencedirect.com/science/article/pii/S2055664020300522
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