Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst

This paper describes the preparation of indoles, azaindoles and benzofurans in pure water by using a new heterogeneous Pd–Cu/C catalyst through a cascade Sonogashira alkynylation–cyclization sequence. Details of the optimization studies and the substrate scope are discussed. This procedure allows th...

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Main Authors:	Cybille Rossy, Eric Fouquet, François-Xavier Felpin
Format:	Article
Language:	English
Published:	Beilstein-Institut 2013-07-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	benzofuran bimetallic catalyst heterogeneous catalysis indole water
Online Access:	https://doi.org/10.3762/bjoc.9.160

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spelling	doaj-5d1f49e032b74d0e90bf193b799b14f82021-02-02T02:28:30ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972013-07-01911426143110.3762/bjoc.9.1601860-5397-9-160Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalystCybille Rossy0Eric Fouquet1François-Xavier Felpin2Université de Bordeaux, UMR CNRS 5255, ISM, 351 cours de la Libération, 33405 Talence Cedex, FranceUniversité de Bordeaux, UMR CNRS 5255, ISM, 351 cours de la Libération, 33405 Talence Cedex, FranceUniversité de Nantes, UFR Sciences et Techniques, UMR CNRS 6230, CEISAM, 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, FranceThis paper describes the preparation of indoles, azaindoles and benzofurans in pure water by using a new heterogeneous Pd–Cu/C catalyst through a cascade Sonogashira alkynylation–cyclization sequence. Details of the optimization studies and the substrate scope are discussed. This procedure allows the preparation of heterocycles with good yields and is tolerant to a wide variety of functional groups.https://doi.org/10.3762/bjoc.9.160benzofuranbimetallic catalystheterogeneous catalysisindolewater
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Cybille Rossy Eric Fouquet François-Xavier Felpin
spellingShingle	Cybille Rossy Eric Fouquet François-Xavier Felpin Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst Beilstein Journal of Organic Chemistry benzofuran bimetallic catalyst heterogeneous catalysis indole water
author_facet	Cybille Rossy Eric Fouquet François-Xavier Felpin
author_sort	Cybille Rossy
title	Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst
title_short	Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst
title_full	Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst
title_fullStr	Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst
title_full_unstemmed	Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst
title_sort	practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst
publisher	Beilstein-Institut
series	Beilstein Journal of Organic Chemistry
issn	1860-5397
publishDate	2013-07-01
description	This paper describes the preparation of indoles, azaindoles and benzofurans in pure water by using a new heterogeneous Pd–Cu/C catalyst through a cascade Sonogashira alkynylation–cyclization sequence. Details of the optimization studies and the substrate scope are discussed. This procedure allows the preparation of heterocycles with good yields and is tolerant to a wide variety of functional groups.
topic	benzofuran bimetallic catalyst heterogeneous catalysis indole water
url	https://doi.org/10.3762/bjoc.9.160
work_keys_str_mv	AT cybillerossy practicalsynthesisofindolesandbenzofuransinwaterusingaheterogeneousbimetalliccatalyst AT ericfouquet practicalsynthesisofindolesandbenzofuransinwaterusingaheterogeneousbimetalliccatalyst AT francoisxavierfelpin practicalsynthesisofindolesandbenzofuransinwaterusingaheterogeneousbimetalliccatalyst
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Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst

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