Characterization, survival analysis, and expression of IGFR in tumor samples from patients diagnosed with Ewing family tumors treated at the Barretos Cancer Hospital

• Main Authors: Adriano Jander Ferreira, Erica Boldrini, Rossana Verónica Mendoza López, Cristovam Scapulatempo Neto, Julie Francine Cerutti Santos, Luiz Fernando Lopes
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Ortopedia e Traumatologia
• Series: Revista Brasileira de Ortopedia
• Subjects: Sarcoma; Ewing; Neuroectodermal tumors; Primitive; Peripheral; Insulin-like growth factor I; Survival analysis; Bone neoplasms; Oncology
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162017000600705&lng=en&tlng=en

ABSTRACT OBJECTIVES: Study the clinical characteristics of patients diagnosed with Ewing family tumors (EFTs) and survival analysis based on risk criteria and expression of the surface protein known as insulin-like growth factor (IGFR). METHODS: This was a retrospective cohort study based on clinical data from 77 patients diagnosed with EFTs treated by the Department of Pediatric Oncology at the Barretos Cancer Hospital in a period between 2003 and 2012. Biological samples of patients were examined for the presence of the surface receptor IGFR. RESULTS: The overall survival rate (OSR) of patients included in the study was 45% at five years, and EFS was 30% at five years. Metastasis at diagnosis was present in 44.2% of the sample; 88.2% of the sample was male (p < 0.001). The evaluation of the expression of IGFR in biological samples of patients was associated with the variable metastasis at diagnosis (p < 0.001). Worse prognosis was observed in patients with extrapulmonary metastasis (p = 0.009). The local treatment of neoplasia presented better prognosis in patients undergoing local surgical treatment (p < 0.001). CONCLUSIONS: These results showed a higher incidence of metastasis at diagnosis in patients with EFTs treated at the Barretos Cancer Hospital (BCH). Extrapulmonary metastases were a negative prognostic factor in this study. Surgical treatment of the primary tumor was a factor for better prognosis. Strong expression of IGFR was more frequent in patients with metastases at diagnosis, but did not represent a prognostic factor for EFTs.