Decorin Protein is Down-regulated in Non-small Cell Lung Cancer Tissue 
and Significantly Associated with Histological Type

Background and objective Decorin is a protein component of the extracellular matrix. It has been proven that decorin plaid an important role in matrix assembly. The protein is also capable of suppressing tumor cell growth. The aim of this study is to examine the protein levels of decorin in tissue s...

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Main Authors: Yongkai WU, Ting XIAO, Min LI, Ying ZHANG, Yanning GAO, Kelin SUN
Format: Article
Language:zho
Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2011-11-01
Series:Chinese Journal of Lung Cancer
Subjects:
Online Access:http://dx.doi.org/10.3779/j.issn.1009-3419.2011.11.03
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spelling doaj-5cfbf60e1eed427397051d7e06f457ec2020-11-24T22:08:16ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872011-11-01141184885210.3779/j.issn.1009-3419.2011.11.03Decorin Protein is Down-regulated in Non-small Cell Lung Cancer Tissue 
and Significantly Associated with Histological TypeYongkai WUTing XIAOMin LIYing ZHANGYanning GAOKelin SUNBackground and objective Decorin is a protein component of the extracellular matrix. It has been proven that decorin plaid an important role in matrix assembly. The protein is also capable of suppressing tumor cell growth. The aim of this study is to examine the protein levels of decorin in tissue samples of non-small cell lung cancer (NSCLC) patients and evaluate its potential clinical value. Methods Decorin protein levels in tumor tissues and corresponding normal tissues from 16 cases of lung squamous cell carcinoma (SCC) were determined by Western blot analysis. Fifty-one NSCLC samples, including both tumor and normal lung tissues, were examined by immunohistochemical (IHC) staining. Results Western blot results showed that decorin protein levels in 75.0% (12/16) of the SCC tumor tissues were lower than those of the corresponding normal lung tissues. IHC results showed that positively stained decorin was detected in only 11.8% of the tumor tissues, significantly lower than that observed in normal alveoli tissues (53.1%, P<0.001). In lung adenocarcinoma (ADC), almost no expression of decorin was observed, in contrast to squamous cell carcinoma (SCC) (P=0.006). Conclusion Decreased levels of decorin in NSCLC tissue samples, particularly ADC cases, indicate that decorin could play a role in lung cancer carcinogenesis.http://dx.doi.org/10.3779/j.issn.1009-3419.2011.11.03DecorinLung neoplasmsDown-regulation
collection DOAJ
language zho
format Article
sources DOAJ
author Yongkai WU
Ting XIAO
Min LI
Ying ZHANG
Yanning GAO
Kelin SUN
spellingShingle Yongkai WU
Ting XIAO
Min LI
Ying ZHANG
Yanning GAO
Kelin SUN
Decorin Protein is Down-regulated in Non-small Cell Lung Cancer Tissue 
and Significantly Associated with Histological Type
Chinese Journal of Lung Cancer
Decorin
Lung neoplasms
Down-regulation
author_facet Yongkai WU
Ting XIAO
Min LI
Ying ZHANG
Yanning GAO
Kelin SUN
author_sort Yongkai WU
title Decorin Protein is Down-regulated in Non-small Cell Lung Cancer Tissue 
and Significantly Associated with Histological Type
title_short Decorin Protein is Down-regulated in Non-small Cell Lung Cancer Tissue 
and Significantly Associated with Histological Type
title_full Decorin Protein is Down-regulated in Non-small Cell Lung Cancer Tissue 
and Significantly Associated with Histological Type
title_fullStr Decorin Protein is Down-regulated in Non-small Cell Lung Cancer Tissue 
and Significantly Associated with Histological Type
title_full_unstemmed Decorin Protein is Down-regulated in Non-small Cell Lung Cancer Tissue 
and Significantly Associated with Histological Type
title_sort decorin protein is down-regulated in non-small cell lung cancer tissue 
and significantly associated with histological type
publisher Chinese Anti-Cancer Association; Chinese Antituberculosis Association
series Chinese Journal of Lung Cancer
issn 1009-3419
1999-6187
publishDate 2011-11-01
description Background and objective Decorin is a protein component of the extracellular matrix. It has been proven that decorin plaid an important role in matrix assembly. The protein is also capable of suppressing tumor cell growth. The aim of this study is to examine the protein levels of decorin in tissue samples of non-small cell lung cancer (NSCLC) patients and evaluate its potential clinical value. Methods Decorin protein levels in tumor tissues and corresponding normal tissues from 16 cases of lung squamous cell carcinoma (SCC) were determined by Western blot analysis. Fifty-one NSCLC samples, including both tumor and normal lung tissues, were examined by immunohistochemical (IHC) staining. Results Western blot results showed that decorin protein levels in 75.0% (12/16) of the SCC tumor tissues were lower than those of the corresponding normal lung tissues. IHC results showed that positively stained decorin was detected in only 11.8% of the tumor tissues, significantly lower than that observed in normal alveoli tissues (53.1%, P<0.001). In lung adenocarcinoma (ADC), almost no expression of decorin was observed, in contrast to squamous cell carcinoma (SCC) (P=0.006). Conclusion Decreased levels of decorin in NSCLC tissue samples, particularly ADC cases, indicate that decorin could play a role in lung cancer carcinogenesis.
topic Decorin
Lung neoplasms
Down-regulation
url http://dx.doi.org/10.3779/j.issn.1009-3419.2011.11.03
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AT minli decorinproteinisdownregulatedinnonsmallcelllungcancertissueandsignificantlyassociatedwithhistologicaltype
AT yingzhang decorinproteinisdownregulatedinnonsmallcelllungcancertissueandsignificantlyassociatedwithhistologicaltype
AT yanninggao decorinproteinisdownregulatedinnonsmallcelllungcancertissueandsignificantlyassociatedwithhistologicaltype
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