Design of Oligonucleotide Carriers: Importance of Polyamine Chain Length

Design of Oligonucleotide Carriers: Importance of Polyamine Chain Length

Amine containing polymers are extensively studied as special carriers for short-chain RNA (13⁻25 nucleotides), which are applied as gene silencing agents in gene therapy of various diseases including cancer. Elaboration of the oligonucleotide carriers requires knowledge about peculiarities...

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Bibliographic Details
Main Authors: Vadim V. Annenkov, Uma Maheswari Krishnan, Viktor A. Pal’shin, Stanislav N. Zelinskiy, Gayathri Kandasamy, Elena N. Danilovtseva
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Polymers
Subjects:
polymeric amines
oligonucleotides
critical length
grafted polyamines
gene delivery
Online Access:https://www.mdpi.com/2073-4360/10/12/1297

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