Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines

Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines

As a part of our ongoing research on endophytic fungi, we have isolated a sesterterpene mycotoxin, fusaproliferin (FUS), from a <i>Fusarium solani </i>strain, which is associated with the plant <i>Aglaonema hookerianum</i> Schott. FUS showed rapid and sub-micromolar IC<sub...

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Bibliographic Details
Main Authors: Nazia Hoque, Choudhury Mahmood Hasan, Md. Sohel Rana, Amrit Varsha, Md. Hossain Sohrab, Khondaker Miraz Rahman
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Molecules
Subjects:
endophytic fungi
sesterterpene
cytotoxic activity
pancreatic cancer
Online Access:https://www.mdpi.com/1420-3049/23/12/3288
Description
Summary:As a part of our ongoing research on endophytic fungi, we have isolated a sesterterpene mycotoxin, fusaproliferin (FUS), from a <i>Fusarium solani </i>strain, which is associated with the plant <i>Aglaonema hookerianum</i> Schott. FUS showed rapid and sub-micromolar IC<sub>50</sub> against pancreatic cancer cell lines. Time-dependent survival analysis and microscopy imaging showed rapid morphological changes in cancer cell lines 4 h after incubation with FUS. This provides a new chemical scaffold that can be further developed to obtain more potent synthetic agents against pancreatic cancer.
ISSN:1420-3049

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