Comparative genomics reveals key gain-of-function events in Foxp3 during regulatory T cell evolution

Comparative genomics reveals key gain-of-function events in Foxp3 during regulatory T cell evolution

The immune system has the ability to suppress undesirable responses, such as those against commensal bacteria, food and paternal antigens in placenta pregnancy. The lineage-specific transcription factor Foxp3 orchestrates the development and function of regulatory T cells underlying this immunologic...

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Bibliographic Details
Main Authors:	Kristian G Andersen, Jesper K Nissen, Alexander G Betz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2012-05-01
Series:	Frontiers in Immunology
Subjects:	Regulatory T Cell Foxp3 Evolution of Immune System Lineage commitment Comparative genomics
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00113/full

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