Ceramide kinase mediates intrinsic resistance and inferior response to chemotherapy in triple‐negative breast cancer by upregulating Ras/ERK and PI3K/Akt pathways

Ceramide kinase mediates intrinsic resistance and inferior response to chemotherapy in triple‐negative breast cancer by upregulating Ras/ERK and PI3K/Akt pathways

Abstract Background Clinical management of triple-negative breast cancer (TNBC) patients remain challenging because of the development of chemo-resistance. Identification of biomarkers for risk stratification of chemo-resistance and therapeutic decision-making to overcome such resistance is thus nec...

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Bibliographic Details
Main Authors: Shan Zhu, Yulin Xu, Lijun Wang, Shichong Liao, Yuan Wang, Manman Shi, Yi Tu, Yurong Zhou, Wen Wei
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Cancer Cell International
Subjects:
CERK
CP-1
TNBC
Chemoresistance
Ras
Biomarker
Online Access:https://doi.org/10.1186/s12935-020-01735-5

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