Aldosterone-Sensitive Nucleus Tractus Solitarius Neurons Regulate Sensitivity of the Baroreceptor Reflex in High Sodium–Loaded Rats

Aldosterone-Sensitive Nucleus Tractus Solitarius Neurons Regulate Sensitivity of the Baroreceptor Reflex in High Sodium–Loaded Rats

We examined the role of aldosterone-sensitive neurons in the nucleus tractus solitarius (NTS) in the arterial baroreceptor reflex (baroreflex) function. Baroreflex sensitivity was induced by phenylephrine in high sodium–loaded rats and was significantly reduced. This baroreflex sensitivity was rever...

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Main Authors: Tomoharu Masuda, Yasutoshi Hirabara, Yusuke Nakamura, Akiko Chishaki, Mai Tsuruhisa, Masayuki Miyakawa, Kenji Honda, Ryo Saito, Hirotaka Sakamoto, Mitsuhiro Kawata, Yukio Takano
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319309879
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spelling doaj-5cec4f249f25433fb3d29b1756f4bfbf2020-11-24T21:49:56ZengElsevierJournal of Pharmacological Sciences1347-86132010-01-011124482486Aldosterone-Sensitive Nucleus Tractus Solitarius Neurons Regulate Sensitivity of the Baroreceptor Reflex in High Sodium–Loaded RatsTomoharu Masuda0Yasutoshi Hirabara1Yusuke Nakamura2Akiko Chishaki3Mai Tsuruhisa4Masayuki Miyakawa5Kenji Honda6Ryo Saito7Hirotaka Sakamoto8Mitsuhiro Kawata9Yukio Takano10Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan; Present address: Department of Pharmacy, University Miyazaki Hospital, Miyazaki 889-1692, JapanDepartment of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan; Present address: Ushimado Marine Laboratory, Graduate School of Natural Science and Technology Okayama University, Okayama 701-4303, JapanDepartment of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan; Corresponding author. takano@fukuoka-u.ac.jpWe examined the role of aldosterone-sensitive neurons in the nucleus tractus solitarius (NTS) in the arterial baroreceptor reflex (baroreflex) function. Baroreflex sensitivity was induced by phenylephrine in high sodium–loaded rats and was significantly reduced. This baroreflex sensitivity was reversed by microinjection of the mineralocorticoid receptor (MR) antagonist eplerenone into the NTS. 11β-Hydroxysteroid dehydrogenase type 2 neurons and MR were also identified in the NTS. These data suggest that the aldosterone-sensitive neurons in the NTS may have an important role in baroreflex function. Keywords:: aldosterone-sensitive nucleus tractus solitarius (NTS) neuron, arterial baroreceptor reflex, mineralocorticoid (MR) antagonist eplerenonehttp://www.sciencedirect.com/science/article/pii/S1347861319309879
collection DOAJ
language English
format Article
sources DOAJ
author Tomoharu Masuda
Yasutoshi Hirabara
Yusuke Nakamura
Akiko Chishaki
Mai Tsuruhisa
Masayuki Miyakawa
Kenji Honda
Ryo Saito
Hirotaka Sakamoto
Mitsuhiro Kawata
Yukio Takano
spellingShingle Tomoharu Masuda
Yasutoshi Hirabara
Yusuke Nakamura
Akiko Chishaki
Mai Tsuruhisa
Masayuki Miyakawa
Kenji Honda
Ryo Saito
Hirotaka Sakamoto
Mitsuhiro Kawata
Yukio Takano
Aldosterone-Sensitive Nucleus Tractus Solitarius Neurons Regulate Sensitivity of the Baroreceptor Reflex in High Sodium–Loaded Rats
Journal of Pharmacological Sciences
author_facet Tomoharu Masuda
Yasutoshi Hirabara
Yusuke Nakamura
Akiko Chishaki
Mai Tsuruhisa
Masayuki Miyakawa
Kenji Honda
Ryo Saito
Hirotaka Sakamoto
Mitsuhiro Kawata
Yukio Takano
author_sort Tomoharu Masuda
title Aldosterone-Sensitive Nucleus Tractus Solitarius Neurons Regulate Sensitivity of the Baroreceptor Reflex in High Sodium–Loaded Rats
title_short Aldosterone-Sensitive Nucleus Tractus Solitarius Neurons Regulate Sensitivity of the Baroreceptor Reflex in High Sodium–Loaded Rats
title_full Aldosterone-Sensitive Nucleus Tractus Solitarius Neurons Regulate Sensitivity of the Baroreceptor Reflex in High Sodium–Loaded Rats
title_fullStr Aldosterone-Sensitive Nucleus Tractus Solitarius Neurons Regulate Sensitivity of the Baroreceptor Reflex in High Sodium–Loaded Rats
title_full_unstemmed Aldosterone-Sensitive Nucleus Tractus Solitarius Neurons Regulate Sensitivity of the Baroreceptor Reflex in High Sodium–Loaded Rats
title_sort aldosterone-sensitive nucleus tractus solitarius neurons regulate sensitivity of the baroreceptor reflex in high sodium–loaded rats
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2010-01-01
description We examined the role of aldosterone-sensitive neurons in the nucleus tractus solitarius (NTS) in the arterial baroreceptor reflex (baroreflex) function. Baroreflex sensitivity was induced by phenylephrine in high sodium–loaded rats and was significantly reduced. This baroreflex sensitivity was reversed by microinjection of the mineralocorticoid receptor (MR) antagonist eplerenone into the NTS. 11β-Hydroxysteroid dehydrogenase type 2 neurons and MR were also identified in the NTS. These data suggest that the aldosterone-sensitive neurons in the NTS may have an important role in baroreflex function. Keywords:: aldosterone-sensitive nucleus tractus solitarius (NTS) neuron, arterial baroreceptor reflex, mineralocorticoid (MR) antagonist eplerenone
url http://www.sciencedirect.com/science/article/pii/S1347861319309879
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AT yukiotakano aldosteronesensitivenucleustractussolitariusneuronsregulatesensitivityofthebaroreceptorreflexinhighsodiumloadedrats
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