More diversity in epithelial cell polarity: A fruit flies' gut feeling.
Multicellular animals face the principle challenge to deal with two distinct compartments: the internal organismal compartment and the external environment. This challenge is met by the differentiation of cell sheets into epithelia, which provide a dynamic barrier in tissues, organs, and organisms....
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Public Library of Science (PLoS)
2018-12-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3000082 |
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doaj-5cdd1efcfe1346db8975170ae83f80962021-07-02T17:07:47ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852018-12-011612e300008210.1371/journal.pbio.3000082More diversity in epithelial cell polarity: A fruit flies' gut feeling.H-Arno J MüllerMulticellular animals face the principle challenge to deal with two distinct compartments: the internal organismal compartment and the external environment. This challenge is met by the differentiation of cell sheets into epithelia, which provide a dynamic barrier in tissues, organs, and organisms. Cell polarity is key to all functions of epithelia, and compromising polarity causes many severe diseases. Within the past 20 years, research on Drosophila melanogaster discovered a conserved molecular machinery that controls epithelial polarity. Recent findings suggest that the textbook Drosophila-based paradigm of the control of epithelial polarity may not be as universal as previously assumed.https://doi.org/10.1371/journal.pbio.3000082 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
H-Arno J Müller |
| spellingShingle |
H-Arno J Müller More diversity in epithelial cell polarity: A fruit flies' gut feeling. PLoS Biology |
| author_facet |
H-Arno J Müller |
| author_sort |
H-Arno J Müller |
| title |
More diversity in epithelial cell polarity: A fruit flies' gut feeling. |
| title_short |
More diversity in epithelial cell polarity: A fruit flies' gut feeling. |
| title_full |
More diversity in epithelial cell polarity: A fruit flies' gut feeling. |
| title_fullStr |
More diversity in epithelial cell polarity: A fruit flies' gut feeling. |
| title_full_unstemmed |
More diversity in epithelial cell polarity: A fruit flies' gut feeling. |
| title_sort |
more diversity in epithelial cell polarity: a fruit flies' gut feeling. |
| publisher |
Public Library of Science (PLoS) |
| series |
PLoS Biology |
| issn |
1544-9173 1545-7885 |
| publishDate |
2018-12-01 |
| description |
Multicellular animals face the principle challenge to deal with two distinct compartments: the internal organismal compartment and the external environment. This challenge is met by the differentiation of cell sheets into epithelia, which provide a dynamic barrier in tissues, organs, and organisms. Cell polarity is key to all functions of epithelia, and compromising polarity causes many severe diseases. Within the past 20 years, research on Drosophila melanogaster discovered a conserved molecular machinery that controls epithelial polarity. Recent findings suggest that the textbook Drosophila-based paradigm of the control of epithelial polarity may not be as universal as previously assumed. |
| url |
https://doi.org/10.1371/journal.pbio.3000082 |
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