Effects of TORC1 Inhibition during the Early and Established Phases of Polycystic Kidney Disease.

Effects of TORC1 Inhibition during the Early and Established Phases of Polycystic Kidney Disease.

The disease-modifying effects of target of rapamycin complex 1 (TORC1) inhibitors during different stages of polycystic kidney disease (PKD) are not well defined. In this study, male Lewis Polycystic Kidney Disease (LPK) rats (a genetic ortholog of human NPHP9, phenotypically characterised by diffus...

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Bibliographic Details
Main Authors: Michelle H T Ta, Kristina G Schwensen, Sheryl Foster, Mayuresh Korgaonkar, Justyna E Ozimek-Kulik, Jacqueline K Phillips, Anthony Peduto, Gopala K Rangan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5056751?pdf=render

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http://europepmc.org/articles/PMC5056751?pdf=render

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