Human hormone-sensitive lipase (HSL): expression in white fat corrects the white adipose phenotype of HSL-deficient mice

Human hormone-sensitive lipase (HSL): expression in white fat corrects the white adipose phenotype of HSL-deficient mice

In white adipose tissue (WAT), hormone-sensitive lipase (HSL) can mediate lipolysis, a central pathway in obesity and diabetes. Gene-targeted HSL-deficient (HSL−/−) mice with no detectable HSL peptide or activity (measured as cholesteryl esterase) have WAT abnormalities, including low mass, marked h...

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Bibliographic Details
Main Authors: Mélanie Fortier, Krishnakant Soni, Nancy Laurin, Shu Pei Wang, Pascale Mauriège, Frank R. Jirik, Grant A. Mitchell
Format: Article
Language:English
Published: Elsevier 2005-09-01
Series:Journal of Lipid Research
Subjects:
hormone-sensitive lipase
adipocyte
mouse
mutation
fat metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520329321

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http://www.sciencedirect.com/science/article/pii/S0022227520329321

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