Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti

Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti

The adult mammalian cochlear sensory epithelium consists of mechanosensory hair cells and supporting cells but hair cells cannot regenerate. Here, the authors identify multipotent progenitors that arise fromEya1-expressing otic cells that can regenerate hair cells in mice after 1 week of age.

Bibliographic Details
Main Authors: Jinshu Xu, Hiroo Ueno, Chelsea Y. Xu, Binglai Chen, Irving L. Weissman, Pin-Xian Xu
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15046
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spelling doaj-5cd0e2b5a4a4481b8d6ad089c0a2794f2021-05-11T07:34:41ZengNature Publishing GroupNature Communications2041-17232017-05-018111710.1038/ncomms15046Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of CortiJinshu Xu0Hiroo Ueno1Chelsea Y. Xu2Binglai Chen3Irving L. Weissman4Pin-Xian Xu5Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount SinaiInstitute of Stem Cell Biology and Regenerative Medicine, Stanford UniversityDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount SinaiDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount SinaiInstitute of Stem Cell Biology and Regenerative Medicine, Stanford UniversityDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount SinaiThe adult mammalian cochlear sensory epithelium consists of mechanosensory hair cells and supporting cells but hair cells cannot regenerate. Here, the authors identify multipotent progenitors that arise fromEya1-expressing otic cells that can regenerate hair cells in mice after 1 week of age.https://doi.org/10.1038/ncomms15046
collection DOAJ
language English
format Article
sources DOAJ
author Jinshu Xu
Hiroo Ueno
Chelsea Y. Xu
Binglai Chen
Irving L. Weissman
Pin-Xian Xu
spellingShingle Jinshu Xu
Hiroo Ueno
Chelsea Y. Xu
Binglai Chen
Irving L. Weissman
Pin-Xian Xu
Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti
Nature Communications
author_facet Jinshu Xu
Hiroo Ueno
Chelsea Y. Xu
Binglai Chen
Irving L. Weissman
Pin-Xian Xu
author_sort Jinshu Xu
title Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti
title_short Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti
title_full Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti
title_fullStr Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti
title_full_unstemmed Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti
title_sort identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of corti
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-05-01
description The adult mammalian cochlear sensory epithelium consists of mechanosensory hair cells and supporting cells but hair cells cannot regenerate. Here, the authors identify multipotent progenitors that arise fromEya1-expressing otic cells that can regenerate hair cells in mice after 1 week of age.
url https://doi.org/10.1038/ncomms15046
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AT hirooueno identificationofmousecochlearprogenitorsthatdevelophairandsupportingcellsintheorganofcorti
AT chelseayxu identificationofmousecochlearprogenitorsthatdevelophairandsupportingcellsintheorganofcorti
AT binglaichen identificationofmousecochlearprogenitorsthatdevelophairandsupportingcellsintheorganofcorti
AT irvinglweissman identificationofmousecochlearprogenitorsthatdevelophairandsupportingcellsintheorganofcorti
AT pinxianxu identificationofmousecochlearprogenitorsthatdevelophairandsupportingcellsintheorganofcorti
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