Meta-analysis of the efficacy of sodium hyaluronate eye drops combined with rhEGF eye drops in the treatment of dry eye after cataract surgery

• Main Authors: Yu Huang, Jie Li, Xiao-Qing Liu, Dong-Dong Li, Li-Hao Chen, Jun Peng, Qing-Hua Peng
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2021-05-01
• Series: Guoji Yanke Zazhi
• Subjects: sodium hyaluronate eye drops; recombinant human epidermal growth factor eye drops; dry eye after cataract surgery; meta-analysis
• Online Access: http://ies.ijo.cn/cn_publish/2021/5/202105021.pdf

AIM: To systematically evaluate the efficacy of sodium hyaluronate combined with recombinant human epidermal growth factor(rhEGF)eye drops in the treatment of dry eye after cataract surgery in recent 5a by Meta-analysis.METHODS: The databases of CNKI, WanFang, Chongqing VIP, CBM, Cochrane Library, Pudmed and MEDLINE from January 2015 to May 2020 were searched. Meta analysis and statistical analysis were performed with Revman 5.3 software on the clinical control study of sodium hyaluronate eye drops combined with rhEGF eye drops in the treatment of dry eye after cataract surgery.RESULTS: A total of 14 randomized controlled trials involving 1 529 eyes were included. Among them, 14 studies conducted corneal fluorescein staining(FL)score after the end of treatment, the results showed that the difference was statistically significant [MD= -0.86, 95%CI(-1.07 to -0.66), P<0.00001]; 14 studies conducted tear film break-up time(BUT)measurement after the end of treatment, the results showed that the difference was statistically significant [MD=2.33, 95%CI(1.64, 3.03), P<0.00001], 95%CI(1.76 to 2.15), P<0.00001]; tear secretion test(S I t)was measured in 12 studies after treatment, and the results showed that there was no significant difference [MD=0.49, 95%Cl(-0.52, 1.50), P=0.34]; the overall effective rate was calculated in 12 studies after treatment, and the results showed that the difference was statistically significant [OR=4.88, 95%Cl(3.34, 1.50), P=0.34]. The results showed that the difference was statistically significant [MD= -1.09, 95%Cl(-1.58, -0.61), P<0.00001].CONCLUSION: Sodium hyaluronate combined with rhEGF eye drops in the treatment of dry eye after cataract surgery can significantly improve the corneal repair ability and tear film BUT, which has more advantages in the overall efficacy of the treatment of dry eye after cataract surgery.