Choline Attenuates Cardiac Fibrosis by Inhibiting p38MAPK Signaling Possibly by Acting on M3 Muscarinic Acetylcholine Receptor

Choline Attenuates Cardiac Fibrosis by Inhibiting p38MAPK Signaling Possibly by Acting on M3 Muscarinic Acetylcholine Receptor

Choline has been reported to produce a variety of cellular functions including cardioprotection via activating M3 muscarinic acetylcholine receptor (M3R) under various insults. However, whether choline offers similar beneficial effects via the same mechanism in cardiac fibrosis remained unexplored....

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Bibliographic Details
Main Authors: Lihui Zhao, Tingting Chen, Pengzhou Hang, Wen Li, Jing Guo, Yang Pan, Jingjing Du, Yuyang Zheng, Zhimin Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
M3 receptor
cardiac fibrosis
choline
collagen
p38MAPK
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01386/full

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