Formyl-methionine as a degradation signal at the N-termini of bacterial proteins
In bacteria, all nascent proteins bear the pretranslationally formed N-terminal formyl-methionine (fMet) residue. The fMet residue is cotranslationally deformylated by a ribosome-associated deformylase. The formylation of N-terminal Met in bacterial proteins is not strictly essential for either tran...
Main Authors: | Konstantin I. Piatkov, Tri T. M. Vu, Cheol-Sang Hwang, Alexander Varshavsky |
---|---|
Format: | Article |
Language: | English |
Published: |
Shared Science Publishers OG
2015-09-01
|
Series: | Microbial Cell |
Subjects: | |
Online Access: | http://microbialcell.com/researcharticles/formyl-methionine-as-a-degradation-signal-at-the-n-termini-of-bacterial-proteins/ |
Similar Items
-
Starting with a degron: N-terminal formyl-methionine of nascent bacterial proteins contributes to their proteolytic control
by: R. Jürgen Dohmen
Published: (2015-10-01) -
Analyse intégrative du rôle de l’excision de la méthionine N-terminale dans le cytoplasme des eucaryotes supérieurs
by: Frottin, Frédéric
Published: (2011) -
Applications of Bacterial Degrons and Degraders — Toward Targeted Protein Degradation in Bacteria
by: Matylda Anna Izert, et al.
Published: (2021-05-01) -
Formylation of Amines
by: Ciera J. Gerack, et al.
Published: (2014-06-01) -
Peptide Deformylase (def) is essential in Mycobacterium smegmatis, but the essentiality is compensated by inactivation of methionine formylation
by: Noga Naor, et al.
Published: (2019-10-01)