A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans
The role of type I interferons in bacterial infection is less clear than it is in viral infection. Here, the authors show that genetic variation of the human IFNAR1 gene is associated with decreased susceptibility to tuberculosis and identify a role for the IFNAR1 inter-domain region in the cytokine...
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| Language: | English |
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Nature Publishing Group
2018-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-02611-z |
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doaj-5ca2351b99a54111a84374d6e929ba772021-05-11T10:24:59ZengNature Publishing GroupNature Communications2041-17232018-01-01911910.1038/s41467-017-02611-zA proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humansGuoliang Zhang0Nicole A. deWeerd1Sebastian A. Stifter2Lei Liu3Boping Zhou4Wenfei Wang5Yiping Zhou6Binwu Ying7Xuejiao Hu8Antony Y. Matthews9Magda Ellis10James A. Triccas11Paul J. Hertzog12Warwick J. Britton13Xinchun Chen14Carl G. Feng15Guangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Third People’s Hospital, Guangdong Medical UniversityHudson Institute of Medical ResearchImmunology and Host Defense Group, Department of Infectious Diseases and Immunology, Sydney Medical School, The University of SydneyGuangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Third People’s Hospital, Guangdong Medical UniversityGuangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Third People’s Hospital, Guangdong Medical UniversityGuangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Third People’s Hospital, Guangdong Medical UniversityDepartment of Respiratory Medicine, Shenzhen Futian Hospital, Sun Yet-sen UniversityDepartment of Laboratory Medicine, West China Hospital, Sichuan UniversityDepartment of Laboratory Medicine, West China Hospital, Sichuan UniversityHudson Institute of Medical ResearchTuberculosis Research Program, Centenary InstituteTuberculosis Research Program, Centenary InstituteHudson Institute of Medical ResearchTuberculosis Research Program, Centenary InstituteGuangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Third People’s Hospital, Guangdong Medical UniversityGuangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Third People’s Hospital, Guangdong Medical UniversityThe role of type I interferons in bacterial infection is less clear than it is in viral infection. Here, the authors show that genetic variation of the human IFNAR1 gene is associated with decreased susceptibility to tuberculosis and identify a role for the IFNAR1 inter-domain region in the cytokine response.https://doi.org/10.1038/s41467-017-02611-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Guoliang Zhang Nicole A. deWeerd Sebastian A. Stifter Lei Liu Boping Zhou Wenfei Wang Yiping Zhou Binwu Ying Xuejiao Hu Antony Y. Matthews Magda Ellis James A. Triccas Paul J. Hertzog Warwick J. Britton Xinchun Chen Carl G. Feng |
| spellingShingle |
Guoliang Zhang Nicole A. deWeerd Sebastian A. Stifter Lei Liu Boping Zhou Wenfei Wang Yiping Zhou Binwu Ying Xuejiao Hu Antony Y. Matthews Magda Ellis James A. Triccas Paul J. Hertzog Warwick J. Britton Xinchun Chen Carl G. Feng A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans Nature Communications |
| author_facet |
Guoliang Zhang Nicole A. deWeerd Sebastian A. Stifter Lei Liu Boping Zhou Wenfei Wang Yiping Zhou Binwu Ying Xuejiao Hu Antony Y. Matthews Magda Ellis James A. Triccas Paul J. Hertzog Warwick J. Britton Xinchun Chen Carl G. Feng |
| author_sort |
Guoliang Zhang |
| title |
A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans |
| title_short |
A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans |
| title_full |
A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans |
| title_fullStr |
A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans |
| title_full_unstemmed |
A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans |
| title_sort |
proline deletion in ifnar1 impairs ifn-signaling and underlies increased resistance to tuberculosis in humans |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-01-01 |
| description |
The role of type I interferons in bacterial infection is less clear than it is in viral infection. Here, the authors show that genetic variation of the human IFNAR1 gene is associated with decreased susceptibility to tuberculosis and identify a role for the IFNAR1 inter-domain region in the cytokine response. |
| url |
https://doi.org/10.1038/s41467-017-02611-z |
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