Histopathological Classification of Breast Cancer Images Using a Multi-Scale Input and Multi-Feature Network

• Main Authors: Taimoor Shakeel Sheikh, Yonghee Lee, Migyung Cho
• Format: Article
• Language: English
• Published: MDPI AG 2020-07-01
• Series: Cancers
• Subjects: breast histopathology; computer-assisted diagnosis; whole slide imaging; multi-class classification; data augmentation
• Online Access: https://www.mdpi.com/2072-6694/12/8/2031

Diagnosis of pathologies using histopathological images can be time-consuming when many images with different magnification levels need to be analyzed. State-of-the-art computer vision and machine learning methods can help automate the diagnostic pathology workflow and thus reduce the analysis time. Automated systems can also be more efficient and accurate, and can increase the objectivity of diagnosis by reducing operator variability. We propose a multi-scale input and multi-feature network (MSI-MFNet) model, which can learn the overall structures and texture features of different scale tissues by fusing multi-resolution hierarchical feature maps from the network’s dense connectivity structure. The MSI-MFNet predicts the probability of a disease on the patch and image levels. We evaluated the performance of our proposed model on two public benchmark datasets. Furthermore, through ablation studies of the model, we found that multi-scale input and multi-feature maps play an important role in improving the performance of the model. Our proposed model outperformed the existing state-of-the-art models by demonstrating better accuracy, sensitivity, and specificity.