A comparison between the effects of propofol–fentanyl with propofol–ketamine for sedation in patients undergoing endoscopic retrograde cholangiopancreatography outside the operating room

• Main Authors: Reza Akhondzadeh, Ali Ghomeishi, Sholeh Nesioonpour, Sanaz Nourizade
• Format: Article
• Language: English
• Published: Elsevier 2016-04-01
• Series: Biomedical Journal
• Subjects: Deep sedation; Endoscopic retrograde cholangiopancreatography; Fentanyl; Ketamine; Propofol
• Online Access: http://www.sciencedirect.com/science/article/pii/S2319417016300737

Background: The efficient and secure techniques of anesthesia and sedation have always been needed for. One of these procedures is endoscopic retrograde cholangiopancreatography (ERCP), due to its painfulness and long duration, has high sensitivity. We compare the effects of propofol–fentanyl (PF) with propofol–ketamine (PK) to sedate patients undergoing ERCP. Methods: In this clinical trial, patients were divided into two groups of 49 people. A group received a pharmaceutical combination of PK, and another group received a pharmaceutical combination of PF. Vital signs of patients, Ramsey Sedation Score, and pain of patients were assessed. The total dosage of used propofol was also recorded. Results: There was no significant difference seen in the patients' hemodynamic characteristics in both groups. Pain at the end of surgery and an hour after it in the PK group was less that was not statistically significant. By Ramsey Sedation Score also significant differences were not seen between groups (p = 0.68). By using total dose of propofol used also a significant difference was not observed between the two groups (p = 0.36). Rate of apnea in PK group was 32% and in the PF group was 63%, which this difference was statistically significant (p < 0.05). Conclusion: A comparison between the two drugs combination shows that although in terms of hemodynamic and sedation criteria both groups were similar, but because of the lower amount of pain and apnea in the PK group, this combination may generally in the ERCP procedure is more efficient and safer.