Identification of CD4(-)CD8(-) double-negative natural killer T cell precursors in the thymus.

BACKGROUND: It is well known that CD1d-restricted Valpha14 invariant natural killer T (NKT) cells are derived from cells in the CD4(+)CD8(+) double-positive (DP) population in the thymus. However, the developmental progression of NKT cells in the earlier stages remains unclear, and the possible exis...

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Bibliographic Details
Main Authors: Nyambayar Dashtsoodol, Hiroshi Watarai, Sakura Sakata, Masaru Taniguchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2577011?pdf=render