Fast, greener and scalable direct coupling of organolithium compounds with no additional solvents

Cross-coupling reactions typically are carried out under dilute conditions of ethereal solvents. Here, the authors report a method for palladium catalysed cross-coupling of organolithium reagents that avoids the use of any added solvent with reaction times of only minutes.

Bibliographic Details
Main Authors: Erik B. Pinxterhuis, Massimo Giannerini, Valentín Hornillos, Ben L. Feringa
Format: Article
Language:English
Published: Nature Publishing Group 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11698
Description
Summary:Cross-coupling reactions typically are carried out under dilute conditions of ethereal solvents. Here, the authors report a method for palladium catalysed cross-coupling of organolithium reagents that avoids the use of any added solvent with reaction times of only minutes.
ISSN:2041-1723