Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy

Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy

Photodynamic therapy (PDT) is able to non-invasively treat and diagnose various cancers and nonmalignant diseases by combining light, oxygen, and photosensitizers (PSs). However, the application of PDT is hindered by poor water solubility and limited light-penetration depth of the currently availabl...

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Main Authors: Jingyao Sun, Semen Kormakov, Ying Liu, Yao Huang, Daming Wu, Zhaogang Yang
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
photodynamic therapy
metal-based nanoparticles
potential toxicity
Online Access:http://www.mdpi.com/1420-3049/23/7/1704
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spelling doaj-5c80815d564f46bb9bc0969bc36bf07a2020-11-25T01:05:57ZengMDPI AGMolecules1420-30492018-07-01237170410.3390/molecules23071704molecules23071704Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic TherapyJingyao Sun0Semen Kormakov1Ying Liu2Yao Huang3Daming Wu4Zhaogang Yang5College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, ChinaCollege of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, ChinaState Key Laboratory of Organic-Inorganic Composites, Beijing 100029, ChinaCollege of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, ChinaCollege of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, ChinaDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USAPhotodynamic therapy (PDT) is able to non-invasively treat and diagnose various cancers and nonmalignant diseases by combining light, oxygen, and photosensitizers (PSs). However, the application of PDT is hindered by poor water solubility and limited light-penetration depth of the currently available photosensitizers (PSs). Water solubility of PSs is crucial for designing pharmaceutical formulation and administration routes. Wavelength of light source at visible range normally has therapeutic depth less than 1 mm. In this review, focus is on the recent research progress of metal-based nanoparticles being applied in PDT. The potential toxicity of these nanoscales and future directions are further discussed.http://www.mdpi.com/1420-3049/23/7/1704photodynamic therapymetal-based nanoparticlespotential toxicity
collection DOAJ
language English
format Article
sources DOAJ
author Jingyao Sun
Semen Kormakov
Ying Liu
Yao Huang
Daming Wu
Zhaogang Yang
spellingShingle Jingyao Sun
Semen Kormakov
Ying Liu
Yao Huang
Daming Wu
Zhaogang Yang
Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy
Molecules
photodynamic therapy
metal-based nanoparticles
potential toxicity
author_facet Jingyao Sun
Semen Kormakov
Ying Liu
Yao Huang
Daming Wu
Zhaogang Yang
author_sort Jingyao Sun
title Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy
title_short Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy
title_full Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy
title_fullStr Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy
title_full_unstemmed Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy
title_sort recent progress in metal-based nanoparticles mediated photodynamic therapy
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2018-07-01
description Photodynamic therapy (PDT) is able to non-invasively treat and diagnose various cancers and nonmalignant diseases by combining light, oxygen, and photosensitizers (PSs). However, the application of PDT is hindered by poor water solubility and limited light-penetration depth of the currently available photosensitizers (PSs). Water solubility of PSs is crucial for designing pharmaceutical formulation and administration routes. Wavelength of light source at visible range normally has therapeutic depth less than 1 mm. In this review, focus is on the recent research progress of metal-based nanoparticles being applied in PDT. The potential toxicity of these nanoscales and future directions are further discussed.
topic photodynamic therapy
metal-based nanoparticles
potential toxicity
url http://www.mdpi.com/1420-3049/23/7/1704
work_keys_str_mv AT jingyaosun recentprogressinmetalbasednanoparticlesmediatedphotodynamictherapy
AT semenkormakov recentprogressinmetalbasednanoparticlesmediatedphotodynamictherapy
AT yingliu recentprogressinmetalbasednanoparticlesmediatedphotodynamictherapy
AT yaohuang recentprogressinmetalbasednanoparticlesmediatedphotodynamictherapy
AT damingwu recentprogressinmetalbasednanoparticlesmediatedphotodynamictherapy
AT zhaogangyang recentprogressinmetalbasednanoparticlesmediatedphotodynamictherapy
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