Impact of tRNA Modifications and tRNA-Modifying Enzymes on Proteostasis and Human Disease

Impact of tRNA Modifications and tRNA-Modifying Enzymes on Proteostasis and Human Disease

Transfer RNAs (tRNAs) are key players of protein synthesis, as they decode the genetic information organized in mRNA codons, translating them into the code of 20 amino acids. To be fully active, tRNAs undergo extensive post-transcriptional modifications, catalyzed by different tRNA-modifying enzymes...

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Bibliographic Details
Main Authors: Marisa Pereira, Stephany Francisco, Ana Sofia Varanda, Mafalda Santos, Manuel A. S. Santos, Ana Raquel Soares
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
transfer RNA
tRNA modifications
tRNA-modifying enzymes
proteostasis
conformational disorders
translation
protein aggregation
Online Access:https://www.mdpi.com/1422-0067/19/12/3738

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