A screen of Coxiella burnetii mutants reveals important roles for Dot/Icm effectors and host autophagy in vacuole biogenesis.

A screen of Coxiella burnetii mutants reveals important roles for Dot/Icm effectors and host autophagy in vacuole biogenesis.

Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-derived vacuole. The molecular mechanisms used by this bacterium to create a pathogen-occupied vacuole remain largely unknown. Here, we conducted a visual screen on an arrayed library of C. burnetii NMII transposon insertio...

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Bibliographic Details
Main Authors: Hayley J Newton, Lara J Kohler, Justin A McDonough, Morayma Temoche-Diaz, Emerson Crabill, Elizabeth L Hartland, Craig R Roy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4117601?pdf=render

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