A Genome-Wide Search for Gene-Environment Effects in Isolated Cleft Lip with or without Cleft Palate Triads Points to an Interaction between Maternal Periconceptional Vitamin Use and Variants in ESRRG

A Genome-Wide Search for Gene-Environment Effects in Isolated Cleft Lip with or without Cleft Palate Triads Points to an Interaction between Maternal Periconceptional Vitamin Use and Variants in ESRRG

Background: It is widely accepted that cleft lip with or without cleft palate (CL/P) results from the complex interplay between multiple genetic and environmental factors. However, a robust investigation of these gene-environment (GxE) interactions at a genome-wide level is still lacking for isolate...

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Bibliographic Details
Main Authors: Øystein A. Haaland, Rolv T. Lie, Julia Romanowska, Miriam Gjerdevik, Håkon K. Gjessing, Astanand Jugessur
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Genetics
Subjects:
gene-environment interaction
GWAS
case-parent triad
orofacial cleft
cleft lip with or without cleft palate
birth defects
Online Access:http://journal.frontiersin.org/article/10.3389/fgene.2018.00060/full

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