Relationship between sensorimotor cortical activation as assessed by functional near infrared spectroscopy and lower extremity motor coordination in bilateral cerebral palsy

Background: Evaluation of task-evoked cortical responses during movement has been limited in individuals with bilateral cerebral palsy (CP), despite documented alterations in brain structure/function and deficits in motor control. Objective: To systematically evaluate cortical activity associated wi...

Full description

Bibliographic Details
Main Authors: Theresa Sukal-Moulton, Ana Carolina de Campos, Katharine E. Alter, Theodore J. Huppert, Diane L. Damiano
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:NeuroImage: Clinical
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158218302353
id doaj-5c68fc8e50244c38880237452876a9b7
record_format Article
spelling doaj-5c68fc8e50244c38880237452876a9b72020-11-25T01:21:15ZengElsevierNeuroImage: Clinical2213-15822018-01-0120275285Relationship between sensorimotor cortical activation as assessed by functional near infrared spectroscopy and lower extremity motor coordination in bilateral cerebral palsyTheresa Sukal-Moulton0Ana Carolina de Campos1Katharine E. Alter2Theodore J. Huppert3Diane L. Damiano4Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, United StatesFederal University of São Carlos, São Carlos, BrazilClinical Center, Rehabilitation Medicine Department, National Institutes of Health, Bethesda, MD, United StatesDepartment of Radiology, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United StatesClinical Center, Rehabilitation Medicine Department, National Institutes of Health, Bethesda, MD, United States; Corresponding author at: National Institutes of Health, 10 Center Drive, Room 1-1469, Bethesda, MD 20892, United States.Background: Evaluation of task-evoked cortical responses during movement has been limited in individuals with bilateral cerebral palsy (CP), despite documented alterations in brain structure/function and deficits in motor control. Objective: To systematically evaluate cortical activity associated with lower extremity tasks, and relate activation parameters to clinical measures in CP. Methods: 28 ambulatory participants (14 with bilateral CP and 14 with typical development) completed five motor tasks (non-dominant ankle dorsiflexion, hip flexion and leg cycling as well as bilateral dorsiflexion and cycling) in a block design while their sensorimotor cortex was monitored using functional near infrared spectroscopy (fNIRS), in addition to laboratory and clinical measures of performance. Results: Main effects for group and task were found for extent of fNIRS activation (number of active channels; p < 0.001 and p = 0.010, respectively), magnitude of activation (sum of beta values; p < 0.001 for both), and number of active muscles (p = 0.001 and p < 0.001, respectively), but no group by task interactions. Collectively, subgroups with CP and especially those with greater impairments, showed higher extent and magnitude of cortical sensorimotor activation as well as higher amounts of concurrent activity in muscles not required for task performance. Magnitude of fNIRS activation during non-dominant dorsiflexion correlated with validated measures of selective control (r = −0.60, p = 0.03), as well as mobility and daily activity (r = −0.55, p = 0.04 and r = −0.52, p = 0.05, respectively) and self-reported gait function (r = −0.68, p = 0.01) in those with CP. Conclusions: The association between higher activity in the sensorimotor cortex and decreased selectivity in cortical organization suggests a potential neural mechanism of motor deficits and target for intervention. Keywords: Brain, Hemodynamic response, Electromyography, Selective motor control, Cerebral palsyhttp://www.sciencedirect.com/science/article/pii/S2213158218302353
collection DOAJ
language English
format Article
sources DOAJ
author Theresa Sukal-Moulton
Ana Carolina de Campos
Katharine E. Alter
Theodore J. Huppert
Diane L. Damiano
spellingShingle Theresa Sukal-Moulton
Ana Carolina de Campos
Katharine E. Alter
Theodore J. Huppert
Diane L. Damiano
Relationship between sensorimotor cortical activation as assessed by functional near infrared spectroscopy and lower extremity motor coordination in bilateral cerebral palsy
NeuroImage: Clinical
author_facet Theresa Sukal-Moulton
Ana Carolina de Campos
Katharine E. Alter
Theodore J. Huppert
Diane L. Damiano
author_sort Theresa Sukal-Moulton
title Relationship between sensorimotor cortical activation as assessed by functional near infrared spectroscopy and lower extremity motor coordination in bilateral cerebral palsy
title_short Relationship between sensorimotor cortical activation as assessed by functional near infrared spectroscopy and lower extremity motor coordination in bilateral cerebral palsy
title_full Relationship between sensorimotor cortical activation as assessed by functional near infrared spectroscopy and lower extremity motor coordination in bilateral cerebral palsy
title_fullStr Relationship between sensorimotor cortical activation as assessed by functional near infrared spectroscopy and lower extremity motor coordination in bilateral cerebral palsy
title_full_unstemmed Relationship between sensorimotor cortical activation as assessed by functional near infrared spectroscopy and lower extremity motor coordination in bilateral cerebral palsy
title_sort relationship between sensorimotor cortical activation as assessed by functional near infrared spectroscopy and lower extremity motor coordination in bilateral cerebral palsy
publisher Elsevier
series NeuroImage: Clinical
issn 2213-1582
publishDate 2018-01-01
description Background: Evaluation of task-evoked cortical responses during movement has been limited in individuals with bilateral cerebral palsy (CP), despite documented alterations in brain structure/function and deficits in motor control. Objective: To systematically evaluate cortical activity associated with lower extremity tasks, and relate activation parameters to clinical measures in CP. Methods: 28 ambulatory participants (14 with bilateral CP and 14 with typical development) completed five motor tasks (non-dominant ankle dorsiflexion, hip flexion and leg cycling as well as bilateral dorsiflexion and cycling) in a block design while their sensorimotor cortex was monitored using functional near infrared spectroscopy (fNIRS), in addition to laboratory and clinical measures of performance. Results: Main effects for group and task were found for extent of fNIRS activation (number of active channels; p < 0.001 and p = 0.010, respectively), magnitude of activation (sum of beta values; p < 0.001 for both), and number of active muscles (p = 0.001 and p < 0.001, respectively), but no group by task interactions. Collectively, subgroups with CP and especially those with greater impairments, showed higher extent and magnitude of cortical sensorimotor activation as well as higher amounts of concurrent activity in muscles not required for task performance. Magnitude of fNIRS activation during non-dominant dorsiflexion correlated with validated measures of selective control (r = −0.60, p = 0.03), as well as mobility and daily activity (r = −0.55, p = 0.04 and r = −0.52, p = 0.05, respectively) and self-reported gait function (r = −0.68, p = 0.01) in those with CP. Conclusions: The association between higher activity in the sensorimotor cortex and decreased selectivity in cortical organization suggests a potential neural mechanism of motor deficits and target for intervention. Keywords: Brain, Hemodynamic response, Electromyography, Selective motor control, Cerebral palsy
url http://www.sciencedirect.com/science/article/pii/S2213158218302353
work_keys_str_mv AT theresasukalmoulton relationshipbetweensensorimotorcorticalactivationasassessedbyfunctionalnearinfraredspectroscopyandlowerextremitymotorcoordinationinbilateralcerebralpalsy
AT anacarolinadecampos relationshipbetweensensorimotorcorticalactivationasassessedbyfunctionalnearinfraredspectroscopyandlowerextremitymotorcoordinationinbilateralcerebralpalsy
AT katharineealter relationshipbetweensensorimotorcorticalactivationasassessedbyfunctionalnearinfraredspectroscopyandlowerextremitymotorcoordinationinbilateralcerebralpalsy
AT theodorejhuppert relationshipbetweensensorimotorcorticalactivationasassessedbyfunctionalnearinfraredspectroscopyandlowerextremitymotorcoordinationinbilateralcerebralpalsy
AT dianeldamiano relationshipbetweensensorimotorcorticalactivationasassessedbyfunctionalnearinfraredspectroscopyandlowerextremitymotorcoordinationinbilateralcerebralpalsy
_version_ 1725131399485194240