Neonatal Enterovirus Myocarditis With Severe Dystrophic Calcification: Novel Treatment With Pocapavir

Dystrophic myocardial calcification occurs in the setting of myocardial injury and normal serum calcium. We present a case of a neonate with prominent dystrophic calcification and severe left ventricular systolic dysfunction in the setting of enterovirus myocarditis. These findings are superbly illu...

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Main Authors:	Samuel G. Wittekind MD, Catherine C. Allen MD, John L. Jefferies MD, MPH, Mantosh S. Rattan MD, Peace C. Madueme MD, BreAnn N. Taylor PharmD, BCPS, Ryan A. Moore MD
Format:	Article
Language:	English
Published:	SAGE Publishing 2017-09-01
Series:	Journal of Investigative Medicine High Impact Case Reports
Online Access:	https://doi.org/10.1177/2324709617729393

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spelling	doaj-5c63b2fa78924a8182664a4546767ac22020-11-25T03:02:56ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962017-09-01510.1177/2324709617729393Neonatal Enterovirus Myocarditis With Severe Dystrophic Calcification: Novel Treatment With PocapavirSamuel G. Wittekind MD0Catherine C. Allen MD1John L. Jefferies MD, MPH2Mantosh S. Rattan MD3Peace C. Madueme MD4BreAnn N. Taylor PharmD, BCPS5Ryan A. Moore MD6Cincinnati Children’s Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USACincinnati Children’s Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USACincinnati Children’s Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USACincinnati Children’s Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USACincinnati Children’s Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USACincinnati Children’s Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USACincinnati Children’s Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USADystrophic myocardial calcification occurs in the setting of myocardial injury and normal serum calcium. We present a case of a neonate with prominent dystrophic calcification and severe left ventricular systolic dysfunction in the setting of enterovirus myocarditis. These findings are superbly illustrated by multiple imaging modalities. The patient was treated with the novel antiviral, pocapavir, in addition to a standard heart failure regimen. The dystrophic calcification persisted but the left ventricle remodeled significantly. To our knowledge, this is the first reported use of pocapavir for this indication. The literature regarding enterovirus myocarditis and pocapavir is briefly reviewed.https://doi.org/10.1177/2324709617729393
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Samuel G. Wittekind MD Catherine C. Allen MD John L. Jefferies MD, MPH Mantosh S. Rattan MD Peace C. Madueme MD BreAnn N. Taylor PharmD, BCPS Ryan A. Moore MD
spellingShingle	Samuel G. Wittekind MD Catherine C. Allen MD John L. Jefferies MD, MPH Mantosh S. Rattan MD Peace C. Madueme MD BreAnn N. Taylor PharmD, BCPS Ryan A. Moore MD Neonatal Enterovirus Myocarditis With Severe Dystrophic Calcification: Novel Treatment With Pocapavir Journal of Investigative Medicine High Impact Case Reports
author_facet	Samuel G. Wittekind MD Catherine C. Allen MD John L. Jefferies MD, MPH Mantosh S. Rattan MD Peace C. Madueme MD BreAnn N. Taylor PharmD, BCPS Ryan A. Moore MD
author_sort	Samuel G. Wittekind MD
title	Neonatal Enterovirus Myocarditis With Severe Dystrophic Calcification: Novel Treatment With Pocapavir
title_short	Neonatal Enterovirus Myocarditis With Severe Dystrophic Calcification: Novel Treatment With Pocapavir
title_full	Neonatal Enterovirus Myocarditis With Severe Dystrophic Calcification: Novel Treatment With Pocapavir
title_fullStr	Neonatal Enterovirus Myocarditis With Severe Dystrophic Calcification: Novel Treatment With Pocapavir
title_full_unstemmed	Neonatal Enterovirus Myocarditis With Severe Dystrophic Calcification: Novel Treatment With Pocapavir
title_sort	neonatal enterovirus myocarditis with severe dystrophic calcification: novel treatment with pocapavir
publisher	SAGE Publishing
series	Journal of Investigative Medicine High Impact Case Reports
issn	2324-7096
publishDate	2017-09-01
description	Dystrophic myocardial calcification occurs in the setting of myocardial injury and normal serum calcium. We present a case of a neonate with prominent dystrophic calcification and severe left ventricular systolic dysfunction in the setting of enterovirus myocarditis. These findings are superbly illustrated by multiple imaging modalities. The patient was treated with the novel antiviral, pocapavir, in addition to a standard heart failure regimen. The dystrophic calcification persisted but the left ventricle remodeled significantly. To our knowledge, this is the first reported use of pocapavir for this indication. The literature regarding enterovirus myocarditis and pocapavir is briefly reviewed.
url	https://doi.org/10.1177/2324709617729393
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Neonatal Enterovirus Myocarditis With Severe Dystrophic Calcification: Novel Treatment With Pocapavir

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