Analysis of risk factors and prognosis of 253 lymph node metastasis in colorectal cancer patients

• Main Authors: Shidong Hu, Songyan Li, Da Teng, Yang Yan, Haiguan Lin, Boyan Liu, Zihe Gao, Shengyu Zhu, Yufeng Wang, Xiaohui Du
• Format: Article
• Language: English
• Published: BMC 2021-06-01
• Series: BMC Surgery
• Subjects: Lymph node dissection; Molecular indexes; Immunohistochemistry
• Online Access: https://doi.org/10.1186/s12893-021-01276-2

Abstract Background This study aimed to explore potential risk factors for 253 lymph node metastasis, and to identify the prognostic impact of 253 lymph node metastasis in colorectal cancer patients. Methods A retrospective study was conducted of 391 colorectal cancer patients who underwent surgical treatments that included 253 lymph node dissection. Clinicopathological features, molecular indexes and 1-year overall survival rates were analyzed. Results Univariate analyses revealed the following risk factors for 253 lymph node metastasis: high preoperative levels of CEA, large tumour max diameters, and numbers of harvested lymph nodes, presence of vessel carcinoma emboli, low level of MSH6 and MLH1 immunohistochemical staining intensity. Multivariate analysis showed that elevated MLH1 immunohistochemical staining intensity was an independent protective factor for 253 lymph node metastasis (OR: 0.969, 95% CI 0.945, 0.994, P = 0.015). A significant difference was found in 1-year overall survival rate between 253 lymph node-positive and lymph node-negative colorectal cancer patients (88.9% vs.75.0%, P < 0.001). Conclusions 253 lymph node-positive colorectal cancer patients had a worse prognosis than the 253 lymph node-negative patients. 253 lymph node dissection may improve the prognosis of colorectal cancer patients with high risk factors for 253 lymph node metastasis.