Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-beta on synaptic plasticity
The leading hypothesis on Alzheimer Disease (AD) is that it is caused by buildup of the peptide amyloid-beta (Abeta), which initially causes dysregulation of synaptic plasticity and eventually causes destruction of synapses and neurons. Pharmacological efforts to limit Abeta buildup have proven inef...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00085/full |