Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth

Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth

Sulindac sulfide, a metabolite of the nonsteroidal antiinflammatory drug (NSAID) sulindac sulfoxide, is effective at reducing tumor burden in both familial adenomatous polyposis patients and in animals with colorectal cancer. Another sulindac sulfoxide metabolite, sulindac sulfone, has been reporte...

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Bibliographic Details
Main Authors: Christopher S. Williams, Angela P. Goldman, Hongmiao Sheng, Jason D. Morrow, Raymond N. DuBois
Format: Article
Language:English
Published: Elsevier 1999-06-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
sulindac
sulindac sulfide
sulindac sulfone
chemoprevention
colorectal cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S147655869980058X

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