Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth

Sulindac sulfide, a metabolite of the nonsteroidal antiinflammatory drug (NSAID) sulindac sulfoxide, is effective at reducing tumor burden in both familial adenomatous polyposis patients and in animals with colorectal cancer. Another sulindac sulfoxide metabolite, sulindac sulfone, has been reporte...

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Main Authors: Christopher S. Williams, Angela P. Goldman, Hongmiao Sheng, Jason D. Morrow, Raymond N. DuBois
Format: Article
Language:English
Published: Elsevier 1999-06-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S147655869980058X
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spelling doaj-5c49b475041c41cb9f63bbf450c64a6c2020-11-24T22:51:31ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55861522-80021999-06-011217017610.1038/sj.neo.7900024Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer GrowthChristopher S. Williams0Angela P. Goldman1Hongmiao Sheng2Jason D. Morrow3Raymond N. DuBois4Department of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, TNDepartment of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, TNDepartment of Surgery, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, TNDepartment of Pharmacology, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, TNDepartment of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, TN Sulindac sulfide, a metabolite of the nonsteroidal antiinflammatory drug (NSAID) sulindac sulfoxide, is effective at reducing tumor burden in both familial adenomatous polyposis patients and in animals with colorectal cancer. Another sulindac sulfoxide metabolite, sulindac sulfone, has been reported to have antitumor properties without inhibiting cyclooxygenase activity. Here we report the effect of sulindac sulfone treatment on the growth of colorectal carcinoma cells. We observed that sulindac sulfide or sulfone treatment of HCA-7 cells led to inhibition of prostaglandin E2 production. Both sulindac sulfide and sulfone inhibited HCA-7 and HCT-116 cell growth in vitro. Sulindac sulfone had no effect on the growth of either HCA-7 or HCT-116 xenografts, whereas the sulfide derivative inhibited HCA-7 growth in vivo. Both sulindac sulfide and sulfone inhibited colon carcinoma cell growth and prostaglandin production in vitro, but sulindac sulfone had no effect on the growth of colon cancer cell xenografts in nude mice. http://www.sciencedirect.com/science/article/pii/S147655869980058Xsulindacsulindac sulfidesulindac sulfonechemopreventioncolorectal cancer
collection DOAJ
language English
format Article
sources DOAJ
author Christopher S. Williams
Angela P. Goldman
Hongmiao Sheng
Jason D. Morrow
Raymond N. DuBois
spellingShingle Christopher S. Williams
Angela P. Goldman
Hongmiao Sheng
Jason D. Morrow
Raymond N. DuBois
Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth
Neoplasia: An International Journal for Oncology Research
sulindac
sulindac sulfide
sulindac sulfone
chemoprevention
colorectal cancer
author_facet Christopher S. Williams
Angela P. Goldman
Hongmiao Sheng
Jason D. Morrow
Raymond N. DuBois
author_sort Christopher S. Williams
title Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth
title_short Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth
title_full Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth
title_fullStr Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth
title_full_unstemmed Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth
title_sort sulindac sulfide, but not sulindac sulfone, inhibits colorectal cancer growth
publisher Elsevier
series Neoplasia: An International Journal for Oncology Research
issn 1476-5586
1522-8002
publishDate 1999-06-01
description Sulindac sulfide, a metabolite of the nonsteroidal antiinflammatory drug (NSAID) sulindac sulfoxide, is effective at reducing tumor burden in both familial adenomatous polyposis patients and in animals with colorectal cancer. Another sulindac sulfoxide metabolite, sulindac sulfone, has been reported to have antitumor properties without inhibiting cyclooxygenase activity. Here we report the effect of sulindac sulfone treatment on the growth of colorectal carcinoma cells. We observed that sulindac sulfide or sulfone treatment of HCA-7 cells led to inhibition of prostaglandin E2 production. Both sulindac sulfide and sulfone inhibited HCA-7 and HCT-116 cell growth in vitro. Sulindac sulfone had no effect on the growth of either HCA-7 or HCT-116 xenografts, whereas the sulfide derivative inhibited HCA-7 growth in vivo. Both sulindac sulfide and sulfone inhibited colon carcinoma cell growth and prostaglandin production in vitro, but sulindac sulfone had no effect on the growth of colon cancer cell xenografts in nude mice.
topic sulindac
sulindac sulfide
sulindac sulfone
chemoprevention
colorectal cancer
url http://www.sciencedirect.com/science/article/pii/S147655869980058X
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AT hongmiaosheng sulindacsulfidebutnotsulindacsulfoneinhibitscolorectalcancergrowth
AT jasondmorrow sulindacsulfidebutnotsulindacsulfoneinhibitscolorectalcancergrowth
AT raymondndubois sulindacsulfidebutnotsulindacsulfoneinhibitscolorectalcancergrowth
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