Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth
Sulindac sulfide, a metabolite of the nonsteroidal antiinflammatory drug (NSAID) sulindac sulfoxide, is effective at reducing tumor burden in both familial adenomatous polyposis patients and in animals with colorectal cancer. Another sulindac sulfoxide metabolite, sulindac sulfone, has been reporte...
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1999-06-01
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doaj-5c49b475041c41cb9f63bbf450c64a6c2020-11-24T22:51:31ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55861522-80021999-06-011217017610.1038/sj.neo.7900024Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer GrowthChristopher S. Williams0Angela P. Goldman1Hongmiao Sheng2Jason D. Morrow3Raymond N. DuBois4Department of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, TNDepartment of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, TNDepartment of Surgery, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, TNDepartment of Pharmacology, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, TNDepartment of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, TN Sulindac sulfide, a metabolite of the nonsteroidal antiinflammatory drug (NSAID) sulindac sulfoxide, is effective at reducing tumor burden in both familial adenomatous polyposis patients and in animals with colorectal cancer. Another sulindac sulfoxide metabolite, sulindac sulfone, has been reported to have antitumor properties without inhibiting cyclooxygenase activity. Here we report the effect of sulindac sulfone treatment on the growth of colorectal carcinoma cells. We observed that sulindac sulfide or sulfone treatment of HCA-7 cells led to inhibition of prostaglandin E2 production. Both sulindac sulfide and sulfone inhibited HCA-7 and HCT-116 cell growth in vitro. Sulindac sulfone had no effect on the growth of either HCA-7 or HCT-116 xenografts, whereas the sulfide derivative inhibited HCA-7 growth in vivo. Both sulindac sulfide and sulfone inhibited colon carcinoma cell growth and prostaglandin production in vitro, but sulindac sulfone had no effect on the growth of colon cancer cell xenografts in nude mice. http://www.sciencedirect.com/science/article/pii/S147655869980058Xsulindacsulindac sulfidesulindac sulfonechemopreventioncolorectal cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christopher S. Williams Angela P. Goldman Hongmiao Sheng Jason D. Morrow Raymond N. DuBois |
spellingShingle |
Christopher S. Williams Angela P. Goldman Hongmiao Sheng Jason D. Morrow Raymond N. DuBois Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth Neoplasia: An International Journal for Oncology Research sulindac sulindac sulfide sulindac sulfone chemoprevention colorectal cancer |
author_facet |
Christopher S. Williams Angela P. Goldman Hongmiao Sheng Jason D. Morrow Raymond N. DuBois |
author_sort |
Christopher S. Williams |
title |
Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth |
title_short |
Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth |
title_full |
Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth |
title_fullStr |
Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth |
title_full_unstemmed |
Sulindac Sulfide, but Not Sulindac Sulfone, Inhibits Colorectal Cancer Growth |
title_sort |
sulindac sulfide, but not sulindac sulfone, inhibits colorectal cancer growth |
publisher |
Elsevier |
series |
Neoplasia: An International Journal for Oncology Research |
issn |
1476-5586 1522-8002 |
publishDate |
1999-06-01 |
description |
Sulindac sulfide, a metabolite of the nonsteroidal antiinflammatory drug (NSAID) sulindac sulfoxide, is effective at reducing tumor burden in both familial adenomatous polyposis patients and in animals with colorectal cancer. Another sulindac sulfoxide metabolite, sulindac sulfone, has been reported to have antitumor properties without inhibiting cyclooxygenase activity. Here we report the effect of sulindac sulfone treatment on the growth of colorectal carcinoma cells. We observed that sulindac sulfide or sulfone treatment of HCA-7 cells led to inhibition of prostaglandin E2 production. Both sulindac sulfide and sulfone inhibited HCA-7 and HCT-116 cell growth in vitro. Sulindac sulfone had no effect on the growth of either HCA-7 or HCT-116 xenografts, whereas the sulfide derivative inhibited HCA-7 growth in vivo. Both sulindac sulfide and sulfone inhibited colon carcinoma cell growth and prostaglandin production in vitro, but sulindac sulfone had no effect on the growth of colon cancer cell xenografts in nude mice.
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topic |
sulindac sulindac sulfide sulindac sulfone chemoprevention colorectal cancer |
url |
http://www.sciencedirect.com/science/article/pii/S147655869980058X |
work_keys_str_mv |
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1725669289299542016 |