FXR activation by obeticholic acid or nonsteroidal agonists induces a human-like lipoprotein cholesterol change in mice with humanized chimeric liver

FXR activation by obeticholic acid or nonsteroidal agonists induces a human-like lipoprotein cholesterol change in mice with humanized chimeric liver

Obeticholic acid (OCA) is a selective farnesoid X receptor (FXR) agonist that regulates bile acid and lipid metabolism. FXR activation induces distinct changes in circulating cholesterol among animal models and humans. The mechanistic basis of these effects has been elusive because of difficulties i...

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Bibliographic Details
Main Authors: Romeo Papazyan, Xueqing Liu, Jingwen Liu, Bin Dong, Emily M. Plummer, Ronald D. Lewis, II, Jonathan D. Roth, Mark A. Young
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Journal of Lipid Research
Subjects:
farnesoid X receptor agonist
LDL cholesterol
chimeric mice
atorvastatin
nuclear receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520330972

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