Chemodivergent assembly of ortho-functionalized phenols with tunable selectivity via rhodium(III)-catalyzed and solvent-controlled C-H activation

Chemodivergent assembly of ortho-functionalized phenols with tunable selectivity via rhodium(III)-catalyzed and solvent-controlled C-H activation

Ortho functionalisation of phenols can be achieved using N-phenoxy amide directing groups. Here a method for chemodivergent C-H alkenylation, alkylation, carboetherification, or [3 + 2] annulation is presented, with product selectivity determined by the choice of solvent.

Bibliographic Details
Main Authors: Haiman Zhang, Shuang Lin, Hui Gao, Kaixin Zhang, Yi Wang, Zhi Zhou, Wei Yi
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-021-00518-x
Description
Summary:Ortho functionalisation of phenols can be achieved using N-phenoxy amide directing groups. Here a method for chemodivergent C-H alkenylation, alkylation, carboetherification, or [3 + 2] annulation is presented, with product selectivity determined by the choice of solvent.
ISSN:2399-3669

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