Microvesicles released from pneumolysin-stimulated lung epithelial cells carry mitochondrial cargo and suppress neutrophil oxidative burst

Abstract Microvesicles (MVs) are cell-derived extracellular vesicles that have emerged as markers and mediators of acute lung injury (ALI). One of the most common pathogens in pneumonia-induced ALI is Streptococcus pneumoniae (Spn), but the role of MVs during Spn lung infection is largely unknown. I...

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Bibliographic Details
Main Authors: E. Letsiou, L. G. Teixeira Alves, D. Fatykhova, M. Felten, T. J. Mitchell, H.C. Müller-Redetzky, A. C. Hocke, M. Witzenrath
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88897-y