MKL1 Mediates TGF-β Induced RhoJ Transcription to Promote Breast Cancer Cell Migration and Invasion

MKL1 Mediates TGF-β Induced RhoJ Transcription to Promote Breast Cancer Cell Migration and Invasion

Differential regulation of gene transcription contributes to cancer metastasis. We investigated the involvement of a Rho GTPase (RhoJ) in breast cancer metastasis focusing on the mechanism underlying RhoJ trans-activation by pro-metastatic cues. We report that expression of RhoJ was up-regulated in...

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Bibliographic Details
Main Authors: Baoyu Chen, Yibiao Yuan, Lina Sun, Junliang Chen, Mengzhu Yang, Yongmei Yin, Yong Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
transcriptional regulation
transcription factors
breast cancer metastasis
RhoJ
MKL1
ERG1
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00832/full

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