Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans

Four new cembranoids, sarcophelegans A–D (1–4) and six known analogues (5–10) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were elucidated through detailed spectroscopic analysis, and the absolute conﬁguration of 1 was conﬁrmed by single-crystal X-ray diffr...

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Main Authors:	Xin Liu, Junsheng Zhang, Qiao Liu, Guihua Tang, Hongsheng Wang, Chengqi Fan, Sheng Yin
Format:	Article
Language:	English
Published:	MDPI AG 2015-07-01
Series:	Molecules
Subjects:	Sarcophyton elegans cembranoids antimigratory activity
Online Access:	http://www.mdpi.com/1420-3049/20/7/13324

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spelling	doaj-5c3be1fd9dee40a8b7891a72eb0188182020-11-24T23:08:31ZengMDPI AGMolecules1420-30492015-07-01207133241333510.3390/molecules200713324molecules200713324Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegansXin Liu0Junsheng Zhang1Qiao Liu2Guihua Tang3Hongsheng Wang4Chengqi Fan5Sheng Yin6School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaEast China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaFour new cembranoids, sarcophelegans A–D (1–4) and six known analogues (5–10) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were elucidated through detailed spectroscopic analysis, and the absolute conﬁguration of 1 was conﬁrmed by single-crystal X-ray diffraction. The antimigratory potential of compounds 1–10 were evaluated and compounds 2 and 6 were found to inhibit human breast tumor MDA-MB-231 cell migration at 10 μM.http://www.mdpi.com/1420-3049/20/7/13324Sarcophyton eleganscembranoidsantimigratory activity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xin Liu Junsheng Zhang Qiao Liu Guihua Tang Hongsheng Wang Chengqi Fan Sheng Yin
spellingShingle	Xin Liu Junsheng Zhang Qiao Liu Guihua Tang Hongsheng Wang Chengqi Fan Sheng Yin Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans Molecules Sarcophyton elegans cembranoids antimigratory activity
author_facet	Xin Liu Junsheng Zhang Qiao Liu Guihua Tang Hongsheng Wang Chengqi Fan Sheng Yin
author_sort	Xin Liu
title	Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans
title_short	Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans
title_full	Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans
title_fullStr	Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans
title_full_unstemmed	Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans
title_sort	bioactive cembranoids from the south china sea soft coral sarcophyton elegans
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2015-07-01
description	Four new cembranoids, sarcophelegans A–D (1–4) and six known analogues (5–10) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were elucidated through detailed spectroscopic analysis, and the absolute conﬁguration of 1 was conﬁrmed by single-crystal X-ray diffraction. The antimigratory potential of compounds 1–10 were evaluated and compounds 2 and 6 were found to inhibit human breast tumor MDA-MB-231 cell migration at 10 μM.
topic	Sarcophyton elegans cembranoids antimigratory activity
url	http://www.mdpi.com/1420-3049/20/7/13324
work_keys_str_mv	AT xinliu bioactivecembranoidsfromthesouthchinaseasoftcoralsarcophytonelegans AT junshengzhang bioactivecembranoidsfromthesouthchinaseasoftcoralsarcophytonelegans AT qiaoliu bioactivecembranoidsfromthesouthchinaseasoftcoralsarcophytonelegans AT guihuatang bioactivecembranoidsfromthesouthchinaseasoftcoralsarcophytonelegans AT hongshengwang bioactivecembranoidsfromthesouthchinaseasoftcoralsarcophytonelegans AT chengqifan bioactivecembranoidsfromthesouthchinaseasoftcoralsarcophytonelegans AT shengyin bioactivecembranoidsfromthesouthchinaseasoftcoralsarcophytonelegans
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Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans

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