TERRA promotes telomere shortening through exonuclease 1-mediated resection of chromosome ends.

TERRA promotes telomere shortening through exonuclease 1-mediated resection of chromosome ends.

The long noncoding telomeric repeat containing RNA (TERRA) is expressed at chromosome ends. TERRA upregulation upon experimental manipulation or in ICF (immunodeficiency, centromeric instability, facial anomalies) patients correlates with short telomeres. To study the mechanism of telomere length co...

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Bibliographic Details
Main Authors: Verena Pfeiffer, Joachim Lingner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3375253?pdf=render

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