Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection

Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection

Enteroviruses (EVs) have long been implicated in the pathogenesis of type 1 diabetes (T1D), and accumulating evidence has associated virus-induced autoimmunity with the loss of pancreatic beta cells in T1D. Inflammatory cytokines including interferons (IFN) form a primary line of defence against vir...

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Bibliographic Details
Main Authors: Pouria Akhbari, Sarah J Richardson, Noel G Morgan
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Microorganisms
Subjects:
enterovirus
Interferon Stimulated Genes (ISG)
Endoplasmic Reticulum (ER) stress
apoptosis
innate immunity
autoimmune disease
Online Access:https://www.mdpi.com/2076-2607/8/9/1419

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