Changes of multifocal electroretinogram in subclinical diabetic retinopathy

• Main Authors: Kai Gong, Dong-Wei Liu, Wei Wang
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2017-10-01
• Series: Guoji Yanke Zazhi
• Subjects: diabetic retinopathy; multifocal electroretinogram; sub-clinical stage
• Online Access: http://ies.ijo.cn/cn_publish/2017/10/201710029.pdf
• ISSN: 1672-5123; 1672-5123

AIM: To investigate the changes of first order kernel(FOK)and second order kernel(SOK)of multifocal electroretinogram(mf-ERG)in detecting the early retinal abnormalities in sub-clinical stage of diabetic retinopathy.<p>METHODS: Totally 32 patients(58 eyes)with type 2 diabetes mellitus(DM)without apparent diabetic retinopathy(DR)were detected by mf-ERG, from June 2014 to May 2015. Thirty cases(60 eyes)of normal control group had also been taken to compare the difference of the amplitude and latency between the two groups.<p>RESULTS: Compared with the control group: there was no statistical difference in the FOK b-wave latency of the diabetic group, and the FOK b-wave amplitude was significantly decreased(<i>t</i>=3.099, <i>P</i>=0.012). The SOK b-wave latency in diabetes group was statistically delayed(<i>t</i>=2.643, <i>P</i>=0.025), and the SOK b-wave amplitude statistically decreased(<i>t</i>=4.833, <i>P</i><0.01). There was no statistically difference in the a-wave latency and amplitude of FOK and SOK. The b-wave amplitude of FOK and SOK was negatively correlated with the course of the disease. However, the b-wave amplitude was not statistically correlated with the duration of diabetes mellitus. <p>CONCLUSION: The function of the post-polar outer and inner retina detected by FOK and SOK had been damage even before retinopathy. The anomaly is mainly reflected by the decreasing amplitude of b-wave.