TIMP-1 Induces α-Smooth Muscle Actin in Fibroblasts to Promote Urethral Scar Formation

TIMP-1 Induces α-Smooth Muscle Actin in Fibroblasts to Promote Urethral Scar Formation

Background/Aims: Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been reported to upregulate in urethral scar. However, the underlying molecular mechanisms remain undefined. Methods: Here, we studied levels of TIMP-1 and α-smooth muscle actin (α-SMA) in the fibroblasts isolated from urethral s...

Full description

Bibliographic Details
Main Authors:	Yinglong Sa, Chao Li, Hongbin Li, Hailin Guo
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2015-04-01
Series:	Cellular Physiology and Biochemistry
Subjects:	Tissue inhibitor of metalloproteinases-1 (TIMP-1) α-smooth muscle actin (α-SMA) Transforming growth factor β 1 (TGFβ1) Epithelial-mesenchymal transition (EMT) Urethral scar
Online Access:	http://www.karger.com/Article/FullText/374028

Similar Items

Regulation of Renal Fibrosis by Macrophage Polarization
by: Bixia Pan, et al.
Published: (2015-02-01)

Platelet-Derived Growth Factor and Transforming Growth Factor β1 Regulate ARDS-Associated Lung Fibrosis Through Distinct Signaling Pathways
by: Xingqi Deng, et al.
Published: (2015-06-01)

Lipocalin 2 Upregulation Protects Hepatocytes from IL1-β-Induced Stress
by: Ying Hu, et al.
Published: (2015-05-01)

Interleukin-1β Promotes Epithelial-Derived Alveolar Elastogenesis via αvβ6 Integrin-Dependent TGF-β Activation
by: Jiarong Wang, et al.
Published: (2015-07-01)

Bone Morphogenetic Protein-7 Inhibits EMT-Associated Genes in Breast Cancer
by: Xuexiang Ying, et al.
Published: (2015-10-01)

Transcription Factor Egr1 is Involved in High Glucose-Induced Proliferation and Fibrosis in Rat Glomerular Mesangial Cells
by: Dan Wang, et al.
Published: (2015-07-01)

Endothelial Cells Regulate Cardiac Myocyte Reorganisation Through β1-Integrin Signalling
by: Yu Zhang, et al.
Published: (2015-03-01)

Mesenchymal Stem Cells Mitigate Cirrhosis through BMP7
by: Bing Li, et al.
Published: (2015-01-01)

Effects of Astragaloside IV Against the TGF-β1-Induced Epithelial-to-Mesenchymal Transition in Peritoneal Mesothelial Cells by Promoting Smad 7 Expression
by: Lu Zhang, et al.
Published: (2015-08-01)

MicroRNA-21 Negatively Regulates Treg Cells Through a TGF-β1/Smad-Independent Pathway in Patients with Coronary Heart Disease
by: Sihui Li, et al.
Published: (2015-09-01)

Activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ) Through NF-κB/Brg1 and TGF-ß1 Pathways Attenuates Cardiac Remodeling in Pressure-Overloaded Rat Hearts
by: Han-Ping Qi, et al.
Published: (2015-01-01)

Inhibitory Effect of NH4Cl Treatment on Renal Tgfß1 Signaling Following Unilateral Ureteral Obstruction
by: Martina Feger, et al.
Published: (2015-09-01)

The Effect of cAMP-PKA Activation on TGF-β1-Induced Profibrotic Signaling
by: Lin Weng, et al.
Published: (2015-07-01)

Integrin β1 Gene Therapy Enhances in Vitro Creation of Tissue-Engineered Cartilage Under Periodic Mechanical Stress
by: Wenwei Liang, et al.
Published: (2015-10-01)

TGF-β Induces Up-Regulation of Chondroitin Sulfate Synthase 1 (CHSY1) in Nucleus Pulposus Cells Through MAPK Signaling
by: Bo Hu, et al.
Published: (2015-09-01)

Up-Regulation Mttp and Apob Gene Expression in Rat Liver is Related to Post-Lipectomy Hypertriglyceridemia
by: Agnieszka Dettlaff-Pokora, et al.
Published: (2015-07-01)

Baicalein Inhibits MMPs Expression via a MAPK-Dependent Mechanism in Chondrocytes
by: Wei-Ping Chen, et al.
Published: (2015-05-01)

Stem Cell Conditioned Culture Media Attenuated Albumin-Induced Epithelial-Mesenchymal Transition in Renal Tubular Cells
by: Junping Hu, et al.
Published: (2015-03-01)

Essays on locating accounting in its national context : the case of Italy
by: Zambon, Stefano
Published: (2002)

Path dependence and institutional reform : a case study on the reform of Italian telecommunications institutions 1979-2007
by: Salerno, Francesco Maria
Published: (2008)

Role for HIF-1α and Downstream Pathways in Regulating Neuronal Injury after Intracerebral Hemorrhage in Diabetes
by: Zhen Yu, et al.
Published: (2015-08-01)

TGF-β Regulates Hepatocellular Carcinoma Progression by Inducing Treg Cell Polarization
by: Yinan Shen, et al.
Published: (2015-03-01)

Exercise Prevents Cardiac Injury and Improves Mitochondrial Biogenesis in Advanced Diabetic Cardiomyopathy with PGC-1α and Akt Activation
by: Hui Wang, et al.
Published: (2015-04-01)

Driver distraction : managing the timing of in-vehicle tasks to improve driver safety
by: Hibberd, Daryl Liam
Published: (2012)

Climate, vegetation and biodiversity : a multiscale study of the south of the Iberian Peninsula
by: Finlayson, Geraldine
Published: (2006)

Sir William Stirling Maxwell as historian of Spanish art
by: Macartney, Hilary
Published: (2003)

Teatro de urgencia : propaganda theatre in the Republican zone during the Spanish Civil War 1936-1939
by: McCarthy, J.
Published: (1997)

Modest Decrease in Pgc1α Results in TAG Accumulation but not in Insulin Resistance in L6 Myotubes
by: Bartlomiej Lukaszuk, et al.
Published: (2015-03-01)

AMP-Activated Protein Kinase α1 Regulates Cardiac Gap Junction Protein Connexin 43 and Electrical Remodeling Following Pressure Overload
by: Ioana Alesutan, et al.
Published: (2015-01-01)

Augmented Rac1 Expression and Activity are Associated with Oxidative Stress and Decline of β Cell Function in Obesity
by: Shutong Zhou, et al.
Published: (2015-04-01)

Toll-Like Receptor 4/Spleen Tyrosine Kinase Complex in High Glucose Signal Transduction of Proximal Tubular Epithelial Cells
by: Won Seok Yang, et al.
Published: (2015-04-01)

Imbalance in extracellular matrix degradation in urethral stricture
by: Prihadi JC, et al.
Published: (2018-11-01)

Exercise Training Protects Against Acute Myocardial Infarction via Improving Myocardial Energy Metabolism and Mitochondrial Biogenesis
by: Lichan Tao, et al.
Published: (2015-08-01)

Anti-Tumor Necrosis Factor-α Therapy in the Management of Psoriasis and B-Chronic Lymphocytic Leukemia
by: Anna Balato, et al.
Published: (2011-03-01)

17β-Estradiol and/or Estrogen Receptor β Attenuate the Autophagic and Apoptotic Effects Induced by Prolonged Hypoxia Through HIF-1α-Mediated BNIP3 and IGFBP-3 Signaling Blockage
by: Dennis Jine-Yuan Hsieh, et al.
Published: (2015-05-01)

The Adipokine Chemerin Induces Apoptosis in Cardiomyocytes
by: Diego Rodríguez-Penas, et al.
Published: (2015-08-01)

Nuclear SMAD2 Restrains Proliferation of Glioblastoma
by: Yunhu Yu, et al.
Published: (2015-03-01)

MicroRNA-146a Induced by Hypoxia Promotes Chondrocyte Autophagy through Bcl-2
by: Fei Zhang, et al.
Published: (2015-10-01)

Protective Effect of Spironolactone on Endothelial-to-Mesenchymal Transition in HUVECs via Notch Pathway
by: Xiao Chen, et al.
Published: (2015-04-01)

Periostin Mediates TGF-β-Induced Epithelial Mesenchymal Transition in Prostate Cancer Cells
by: Qingfeng Hu, et al.
Published: (2015-05-01)