Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2.

Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2.

Dot1l encodes histone H3 K79 methyltransferase Dot1a. Mice with Dot1l deficiency in renal Aqp2-expressing cells (Dot1l(AC)) develop polyuria by unknown mechanisms. Here, we report that Aqp5 links Dot1l deletion to polyuria through Aqp2. cDNA array analysis revealed and real-time RT-qPCR validated Aq...

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Bibliographic Details
Main Authors: Hongyu Wu, Lihe Chen, Xi Zhang, Qiaoling Zhou, Ju-Mei Li, Stefan Berger, Zea Borok, Beiyun Zhou, Zhou Xiao, Hongling Yin, Mingyao Liu, Ying Wang, Jianping Jin, Michael R Blackburn, Yang Xia, Wenzheng Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3542343?pdf=render

Internet

http://europepmc.org/articles/PMC3542343?pdf=render

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