Summary: | The assessment of ventilatory efficiency is critical to understanding the matching of ventilation (VE) and perfusion in the lungs during exercise. This study aimed to establish a causal physiological relationship between ventilatory efficiency and resistance exercise performance after beetroot juice (BJ) intake. Eleven well-trained males performed a resistance exercise test after drinking 140 mL of BJ (~12.8 mmol NO<sub>3</sub><sup>−</sup>) or a placebo (PL). Ventilatory efficiency was assessed by the VE•VCO<sub>2</sub><sup>−1</sup> slope, the oxygen uptake efficiency slope and the partial pressure of end-tidal carbon dioxide (PetCO<sub>2</sub>). The two experimental conditions were controlled using a randomized, double-blind crossover design. The resistance exercise test involved repeating the same routine twice, which consisted of wall ball shots plus a full squat (FS) with a 3 min rest or without a rest between the two exercises. A higher weight lifted was detected in the FS exercise after BJ intake compared with the PL during the first routine (<i>p</i> = 0.004). BJ improved the VE•VCO<sub>2</sub><sup>−1</sup> slope and the PetCO<sub>2</sub> during the FS exercise in the first routine and at rest (<i>p</i> < 0.05). BJ intake improved the VE•VCO<sub>2</sub><sup>−1</sup> slope and the PetCO<sub>2</sub> coinciding with the resistance exercise performance. The ergogenic effect of BJ could be induced under aerobic conditions at rest.
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