Anti-Migratory Effects of 4′-Geranyloxyferulic Acid on LPS-Stimulated U937 and HCT116 Cells via MMP-9 Down-Regulation: Involvement of ROS/ERK Signaling Pathway

Anti-Migratory Effects of 4′-Geranyloxyferulic Acid on LPS-Stimulated U937 and HCT116 Cells via MMP-9 Down-Regulation: Involvement of ROS/ERK Signaling Pathway

Matrix metalloproteinases (MMPs) play a crucial role in tumor angiogenesis, and metastasis. 4′-geranyloxyferulic acid (GOFA) has anti-tumor and anti-inflammatory proprieties. Herein, we aimed to determine whether this compound affects cell survival, invasion, and migration through reactive oxygen sp...

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Bibliographic Details
Main Authors: Sara Franceschelli, Daniela Maria Pia Gatta, Alessio Ferrone, Giulia Mezza, Lorenza Speranza, Mirko Pesce, Alfredo Grilli, Marialucia Gallorini, Viviana Di Giacomo, Barbara Ghinassi, Serena Fiorito, Salvatore Genovese, Emanuela Ricciotti, Mario Felaco, Antonia Patruno
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Antioxidants
Subjects:
proliferation
migration
apoptosis
senescence
metalloproteinase
colorectal cancer cells
Online Access:https://www.mdpi.com/2076-3921/9/6/470

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