Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

The Rad53 DNA checkpoint protein kinase plays multiple roles in the budding yeast cell response to DNA replication stress. Key amongst these is its enigmatic role in safeguarding DNA replication forks. Using DNA replication reactions reconstituted with purified proteins, we show Rad53 phosphorylatio...

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Bibliographic Details
Main Authors: Allison W McClure, John FX Diffley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
dna replication
dna checkpoint
biochemistry
Online Access:https://elifesciences.org/articles/69726

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