Ascorbic Acid-Induced Cardiac Differentiation of Murine Pluripotent Stem Cells: Transcriptional Profiling and Effect of a Small Molecule Synergist of Wnt/β-Catenin Signaling Pathway

Ascorbic Acid-Induced Cardiac Differentiation of Murine Pluripotent Stem Cells: Transcriptional Profiling and Effect of a Small Molecule Synergist of Wnt/β-Catenin Signaling Pathway

Background: Reproducible and efficient differentiation of pluripotent stem cells (PSCs) to cardiomyocytes (CMs) is essential for their use in regenerative medicine, drug testing and disease modeling. The aim of this study was to evaluate the effect of some previously reported cardiogenic substances...

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Bibliographic Details
Main Authors: Dina Ivanyuk, Galina Budash, Yunjie Zheng, John Antony Gaspar, Umesh Chaudhari, Azra Fatima, Soghra Bahmanpour, Vladislav K. Grin, Andrey G. Popandopulo, Agapios Sachinidis, Jürgen Hescheler, Tomo Šarić
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Pluripotent stem cells
Cardiomyocytes
Differentiation
Transcriptome
Sscorbic acid
Wnt pathway
Small molecules
Ipsc
ESC
Online Access:http://www.karger.com/Article/FullText/430140

Internet

http://www.karger.com/Article/FullText/430140

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