Interaction of the neuroendocrine and immune mechanisms of progression of myocardial damage

Interaction of the neuroendocrine and immune mechanisms of progression of myocardial damage

The review summarizes data on the interference of the neuroendocrine and immune mechanisms of myocardial remodeling. It shows a role of the effectors of the renin-angiotensin-aldosterone (aldosterone and angiotensin II) and sympathoadrenal (noradrenaline) systems in the activation of macrophages, th...

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Bibliographic Details
Main Authors: Mikhail Yakovlevich Krasnosel'skiy, Pavel Andreevich Vorob'ev, Vladimir Viktorovich Tsurko, M Ya Krasnoselsky, P A Vorobyev, V V Tsurko
Format: Article
Language:Russian
Published: "Consilium Medicum" Publishing house 2010-09-01
Series:Терапевтический архив
Subjects:
myocardial remodeling
neuroendocrine activation
proinflammatory cytokines
inflammation
Online Access:https://ter-arkhiv.ru/0040-3660/article/view/30695
Description
Summary:The review summarizes data on the interference of the neuroendocrine and immune mechanisms of myocardial remodeling. It shows a role of the effectors of the renin-angiotensin-aldosterone (aldosterone and angiotensin II) and sympathoadrenal (noradrenaline) systems in the activation of macrophages, the production of proinflammatory cytokines and inflammatory cell chemoattractants. It is noted that proinflammatory cytokines in turn promote the activation of these neuroendocrine systems. Natriuretic peptides exert an anti-inflammatory effect, but their production can be activated by proinflammatory cytokines.
ISSN:0040-3660
2309-5342

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