Modification of Adenosine196 by Mettl3 Methyltransferase in the 5’-External Transcribed Spacer of 47S Pre-rRNA Affects rRNA Maturation

Modification of Adenosine196 by Mettl3 Methyltransferase in the 5’-External Transcribed Spacer of 47S Pre-rRNA Affects rRNA Maturation

Ribosome biogenesis is among the founding processes in the cell. During the first stages of ribosome biogenesis, polycistronic precursor of ribosomal RNA passes complex multistage maturation after transcription. Quality control of preribosomal RNA (pre-rRNA) processing is precisely regulated by non-...

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Bibliographic Details
Main Authors: Olga Sergeeva, Philipp Sergeev, Pavel Melnikov, Tatiana Prikazchikova, Olga Dontsova, Timofei Zatsepin
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
RNA modification
RNA methyltransferase
rRNA processing
Online Access:https://www.mdpi.com/2073-4409/9/4/1061

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