Epigenetic Repression of miR-218 Promotes Esophageal Carcinogenesis by Targeting ROBO1

Epigenetic Repression of miR-218 Promotes Esophageal Carcinogenesis by Targeting ROBO1

miR-218, consisting of miR-218-1 at 4p15.31 and miR-218-2 at 5q35.1, was significantly decreased in esophageal squamous cell carcinoma (ESCC) in our previous study. The aim of this study was to determine whether aberrant methylation is associated with miR-218 repression. Bisulfite sequencing analysi...

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Bibliographic Details
Main Authors: Miao Yang, Ran Liu, Xiajun Li, Juan Liao, Yuepu Pu, Enchun Pan, Yi Wang, Lihong Yin
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:International Journal of Molecular Sciences
Subjects:
miR-218
CpG methylation
esophageal cancer
ROBO1
Online Access:http://www.mdpi.com/1422-0067/16/11/26062

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