The BHMT-betaine methylation pathway epigenetically modulates oligodendrocyte maturation.

Research into the epigenome is of growing importance as a loss of epigenetic control has been implicated in the development of neurodegenerative diseases. Previous studies have implicated aberrant DNA and histone methylation in multiple sclerosis (MS) disease pathogenesis. We have previously reporte...

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Bibliographic Details
Main Authors: Sarah Sternbach, Nicole West, Naveen K Singhal, Robert Clements, Soumitra Basu, Ajai Tripathi, Ranjan Dutta, Ernest J Freeman, Jennifer McDonough
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0250486