PAR2 Activation on Human Kidney Tubular Epithelial Cells Induces Tissue Factor Synthesis, That Enhances Blood Clotting

PAR2 Activation on Human Kidney Tubular Epithelial Cells Induces Tissue Factor Synthesis, That Enhances Blood Clotting

Coagulation abnormalities and increased risk of atherothrombosis are common in patients with chronic kidney diseases (CKD). Mechanisms that alter renal hemostasis and lead to thrombotic events are not fully understood. Here we show that activation of protease activated receptor-2 (PAR2) on human kid...

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Bibliographic Details
Main Authors: Abishek Iyer, Tyrone L. R. Humphries, Evan P. Owens, Kong-Nan Zhao, Paul P. Masci, David W. Johnson, David Nikolic-Paterson, Glenda C. Gobe, David P. Fairlie, David A. Vesey
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Physiology
Subjects:
protease
PAR2
tissue factor
kidney tubular epithelial cells
coagulation
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.615428/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.615428/full

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